Sutcliffe Catherine G, Grant Lindsay R, Reid Angelina, Douglass Grace, Brown Laura B, Kellywood Kamellia, Weatherholtz Robert C, Hubler Robin, Quintana Alvaro, Close Ryan, McAuley James B, Santosham Mathuram, O'Brien Katherine L, Hammitt Laura L
Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Pfizer Vaccine Medical Development, Scientific and Clinical Affairs, Collegeville, Pennsylvania, USA.
Open Forum Infect Dis. 2020 Feb 22;7(3):ofaa061. doi: 10.1093/ofid/ofaa061. eCollection 2020 Mar.
This study was done to determine the burden of invasive on the White Mountain Apache Tribal lands.
Active population and laboratory-based surveillance for invasive infections was conducted from May 2016 to April 2018. A case was defined as a Native American individual living on or around the White Mountain Apache Tribal lands with isolated from a normally sterile body site.
Fifty-three cases were identified. Most cases were adults (90.6%) and had ≥1 underlying medical condition (86.8%), the most common of which were diabetes (49.1%) and obesity (41.5%). A total of 26.4% cases were categorized as community acquired. Most infections were methicillin-resistant (75.5%). A total of 7.5% of cases required amputation, and 7.7% of cases died within 30 days of initial culture. The incidence of invasive was 156.3 per 100 000 persons. The age-adjusted incidence of invasive methicillin-resistant was 138.2 per 100 000 persons.
This community has a disproportionately high burden of invasive methicillin-resistant compared with the general US population. Interventions are urgently needed to reduce the morbidity and mortality associated with these infections.
本研究旨在确定怀特山阿帕奇部落土地上侵袭性感染的负担。
于2016年5月至2018年4月开展了针对侵袭性感染的主动人群监测和基于实验室的监测。病例定义为居住在怀特山阿帕奇部落土地上或其周边的美洲原住民个体，且从通常无菌的身体部位分离出[具体感染病原体未明确写出]。
共识别出53例病例。大多数病例为成年人（90.6%），且患有≥1种基础疾病（86.8%），其中最常见的是糖尿病（49.1%）和肥胖症（41.5%）。共有26.4%的病例被归类为社区获得性感染。大多数感染为耐甲氧西林感染（75.5%）。共有7.5%的病例需要截肢，7.7%的病例在初次培养后30天内死亡。侵袭性[具体感染病原体未明确写出]的发病率为每10万人156.3例。年龄调整后的耐甲氧西林侵袭性[具体感染病原体未明确写出]发病率为每10万人138.2例。
与美国普通人群相比，该社区耐甲氧西林侵袭性[具体感染病原体未明确写出]的负担极高。迫切需要采取干预措施以降低与这些感染相关的发病率和死亡率。
