Biomedical Center, Physiological Chemistry, Ludwig-Maximilians-University of Munich, Planegg-Martinsried, Germany.
Nucleus. 2020 Dec;11(1):32-34. doi: 10.1080/19491034.2020.1741304.
Bromodomain AAA+ ATPases (TPases ssociated with diverse cellular ctivities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho . reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.
溴结构域 AAA+ ATP 酶（与多种细胞 ctivities 相关的 TPases）正在成为致癌蛋白和抗癌治疗的有吸引力的靶点。然而，这些机器的结构和生化见解仍然缺乏。最近 Cho 的一项研究报告了第一个溴结构域 AAA+ ATP 酶的冷冻电镜结构，并提供了对这种假定的组蛋白伴侣功能的初步了解。
