Samson H H, Tolliver G A, Pfeffer A O, Sadeghi K, Haraguchi M
Alcohol and Drug Abuse Institute, University of Washington, Seattle 98195.
Alcohol. 1988 Sep-Oct;5(5):375-85. doi: 10.1016/0741-8329(88)90024-9.
Free-feeding male Long-Evans rats (N = 8) were initiated to self-administer 10% ethanol using a sucrose-fading procedure. Following initiation, they were placed into chambers which allowed for the continuous monitoring of feeding, water drinking and ethanol self-administration. All rats continued to daily self-administer ethanol in the continuous access situation. Ethanol drinking at certain times during the day appeared to be related to feeding bouts (prandial drinking). However, at other times, nonprandial ethanol self-administration occurred. These nonprandial ethanol drinking episodes, while not at levels of excessive ethanol intakes, were at levels well above water intake when water was substituted for ethanol. These findings suggest that ethanol intake in continuous access conditions is not solely a function of feeding behavior and that following initiation, ethanol-seeking behavior was maintained in a continuous access situation.
自由进食的雄性Long-Evans大鼠（N = 8）采用蔗糖递减程序开始自我给药10%乙醇。开始给药后，将它们放入可对进食、饮水和乙醇自我给药进行持续监测的实验箱中。在持续给药的情况下，所有大鼠继续每日自我给药乙醇。白天某些时段的乙醇饮用似乎与进食发作（进餐时饮用）有关。然而，在其他时段，出现了非进餐时的乙醇自我给药情况。这些非进餐时的乙醇饮用发作，虽然未达到过量乙醇摄入水平，但在用水替代乙醇时，其水平远高于水的摄入量。这些发现表明，在持续给药条件下的乙醇摄入不仅仅是进食行为的函数，并且在开始给药后，在持续给药情况下，寻求乙醇的行为得以维持。
