Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA.
Center on Human Development and Disability, University of Washington, Seattle, WA 98195, USA.
Cells. 2020 Mar 17;9(3):733. doi: 10.3390/cells9030733.
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood. Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for cardiovascular disease.
慢性胎儿缺氧和感染是复杂妊娠期间的不利情况的例子，它们会影响心肌发生并增加心脏病的终身风险。然而，慢性缺氧或炎症环境对心脏起搏细胞的影响还知之甚少。在这里，我们回顾了围产期心脏发生领域的当前证据和新的 bench-to-bed 研究途径，以及其对早期检测未来心血管疾病风险的转化意义。
Zotero 插件