核苷（酸）类似物治疗期间慢性乙型肝炎患者治疗中血清 Mac-2 结合蛋白糖基化异构体（M2BPGi）水平与肝细胞癌发展风险的关系。
On-treatment Serum Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) Level and Risk of Hepatocellular Carcinoma Development in Patients with Chronic Hepatitis B during Nucleot(s)ide Analogue Therapy.
机构信息
Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka 410-2295, Japan.
出版信息
Int J Mol Sci. 2020 Mar 17;21(6):2051. doi: 10.3390/ijms21062051.
We aimed to analyze the serum level of a novel fibrosis marker, Mac-2-binding protein glycosylation isomer (M2BPGi), and its predictive value for hepatocellular carcinoma (HCC) development in chronic hepatitis B (CHB) under nucleot(s)ide analogue (NA) therapy. Serum M2BPGi levels were quantified in 147 CHB patients at baseline, 48 weeks after starting NA therapy, and at the patients' last visit. The serum M2BPGi level serially decreased at each time point. During the median follow-up time of 6.6 years, 14 of 147 patients developed HCC. Multivariate Cox proportional hazard analysis demonstrated that high serum M2BPGi at 48 weeks was an independent risk factor for HCC development. A cutoff value of M2BPGi at 48 weeks > 1.5 showed an adjusted hazard ratio = 34.9 (95% confidence interval, 4.3-284.9). The 3- and 5-year cumulative incidence of HCC in patients with low M2BPGi were 0.9% and 4.2%, respectively, whereas those in patients with high M2BPGi were 10.1% and 25.6%, respectively ( < 0.001). In conclusion, Serum M2BPGi level at 48 weeks is a useful predictor for HCC development in patients with CHB who receive NA therapy.
我们旨在分析一种新型纤维化标志物——Mac-2 结合蛋白糖基化异构体（M2BPGi）的血清水平及其在核苷（酸）类似物（NA）治疗慢性乙型肝炎（CHB）患者中的预测肝细胞癌（HCC）发生的价值。在基线、开始 NA 治疗后 48 周和患者最后一次就诊时，对 147 例 CHB 患者的血清 M2BPGi 水平进行了定量检测。血清 M2BPGi 水平在每个时间点均呈连续下降趋势。在中位数为 6.6 年的随访期间，147 例患者中有 14 例发生 HCC。多变量 Cox 比例风险分析表明，48 周时高血清 M2BPGi 是 HCC 发展的独立危险因素。48 周时 M2BPGi 的截断值>1.5 时，调整后的危险比=34.9（95%置信区间，4.3-284.9）。低 M2BPGi 患者的 3 年和 5 年 HCC 累积发生率分别为 0.9%和 4.2%，而高 M2BPGi 患者的 HCC 累积发生率分别为 10.1%和 25.6%（<0.001）。总之，在接受 NA 治疗的 CHB 患者中，48 周时的血清 M2BPGi 水平是 HCC 发生的一个有用预测因子。
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