Liang Y F, Huang X M, Wen L L, Kang H, Tao M H, Ye M Z
Department of Obstetrics and Gynecology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, China.
Zhonghua Yi Xue Za Zhi. 2020 Mar 17;100(10):771-774. doi: 10.3760/cma.j.cn112137-20191205-02659.
To explore the association between serum brain-derived neurotrophic factor and clinical stage and dysmenorrhoea of endometriosis. A total of 82 patients were studied with laparoscopically diagnosed endometriosis between June 2017 and June 2019, and 75 healthy women with reproductive age were selected as the control group during the same period. The endometriosis patients were scored by visual analogue scale(VAS)according to their preoperative dysmenorrhoea.And endometriosis was staged and scored according to the score of Revised American Fertility Society(r-AFS).Enzyme-linked immunosorbent assay (ELISA) was used to determine preoperative BDNF level in serum, and the correlation between BDNF level with clinical stage as well as dysmenorrhea of endometriosis were analysed. The serum BDNF level in endometriosis patients was (1 082±43) ng/L, significantly higher than that in the normal control [(649±30) ng/L], there was statistical difference between the two groups(0.001). The BDNF expression in patients with r-AFS stage Ⅲ-Ⅳ was higher than that in patients with Ⅰ-Ⅱ stage [(1 164±389) ng/L vs (791±218)ng/L, 0.001]. BDNF level in serum was closely correlated with the degree of dysmenorrhea (0.682), and the BDNF level in patients with moderate or severe dysmenorrhea was significantly higher than that in patients without dysmenorrhea and patients with mild dysmenorrhea [(1 292±43) ng/L vs(718±36) ng/L, 0.001]. The serum BDNF level in endometriosis patients is positively correlated with clinical stage and dysmenorrhea.
探讨血清脑源性神经营养因子与子宫内膜异位症临床分期及痛经的关系。选取2017年6月至2019年6月间经腹腔镜诊断为子宫内膜异位症的患者82例，并同期选取75例育龄期健康女性作为对照组。子宫内膜异位症患者术前痛经情况采用视觉模拟评分法（VAS）进行评分，子宫内膜异位症根据修订的美国生育协会（r-AFS）评分进行分期和评分。采用酶联免疫吸附测定（ELISA）法测定术前血清BDNF水平，并分析BDNF水平与子宫内膜异位症临床分期及痛经的相关性。子宫内膜异位症患者血清BDNF水平为（1082±43）ng/L，显著高于正常对照组[（649±30）ng/L]，两组间差异有统计学意义（P<0.001）。r-AFSⅢ-Ⅳ期患者BDNF表达高于Ⅰ-Ⅱ期患者[（1164±389）ng/L比（791±218）ng/L，P<0.001]。血清BDNF水平与痛经程度密切相关（r=0.682），中重度痛经患者BDNF水平显著高于无痛经及轻度痛经患者[（1292±43）ng/L比（718±36）ng/L，P<0.001]。子宫内膜异位症患者血清BDNF水平与临床分期及痛经呈正相关。
