诊断双侧弥漫性葡萄膜黑素细胞增生揭示原发性胃腺癌：一例报告。
Diagnosis of bilateral diffuse uveal melanocytic proliferation unveils primary gastric adenocarcinoma: a case report.
机构信息
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Key Lab of Ocular Fundus Disease, Chinese Academy of Medical Sciences, Beijing, 100730, China.
出版信息
BMC Ophthalmol. 2020 Mar 19;20(1):113. doi: 10.1186/s12886-020-01376-2.
BACKGROUND
Bilateral diffuse uveal melanocytic proliferation (BDUMP) is an extremely rare paraneoplastic syndrome, with most cases reported as secondary to female urogenital and male lung malignancies. We reported this case of BDUMP patient whose primary malignancy was gastric adenocarcinoma verified with gastroscopy and subsequent pathological test.
CASE PRESENTATION
A patient complaining blurred vision was suspected of bilateral diffuse uveal melanocytic proliferation (BDUMP), due to bilateral round oval patches at the posterior pole and cardinal signs in retinal angiography. Malignancy screening was suggested, and pathological report from gastroscopy confirmed the primary lesion as gastric adenocarcinoma. The patient chose palliative care due to late stage and unresectable nature of the malignancy.
CONCLUSIONS
Identifying BDUMP warrants further investigation of a primary malignancy. Our case provided evidence for the link between gastric adenocarcinoma and BDUMP.
背景
双侧弥漫性葡萄膜黑色素细胞增生（BDUMP）是一种极为罕见的副瘤综合征，大多数病例继发于女性泌尿生殖系统和男性肺部恶性肿瘤。我们报告了一例 BDUMP 患者，其主要恶性肿瘤经胃镜和随后的病理检查证实为胃腺癌。
病例介绍
一名主诉视力模糊的患者被怀疑患有双侧弥漫性葡萄膜黑色素细胞增生（BDUMP），因为眼底血管造影显示后极部有双侧圆形椭圆形斑块和 cardinal 征。建议进行恶性肿瘤筛查，胃镜的病理报告证实原发性病变为胃腺癌。由于恶性肿瘤已处于晚期且无法切除，患者选择姑息治疗。
结论
识别 BDUMP 需要进一步调查原发性恶性肿瘤。我们的病例为胃腺癌和 BDUMP 之间的关联提供了证据。
Zotero 插件