Gülhane Training and Research Hospital, Department of Gynecology and Obstetrics Reproductive Medical Center, University of Health SciencesEtlik, Ankara, Turkey.
Zygote. 2020 Jun;28(3):191-195. doi: 10.1017/S0967199419000777. Epub 2020 Mar 20.
The objective of this study was to compare the rates of clinical pregnancy after the transfer of vitrified and thawed human embryos on days 3, 4 and 5 of embryonic development. In this retrospective study, the results of 148 embryo transfer cycles, using embryos frozen and thawed over the 3-year period between January 2016 and December 2018 at the Gülhane Training and Research Hospital Department of Gynecology and Obsterics Reproductive Medical Center of the University of Health Sciences, Ankara, Turkey were examined. Following embryo transfer - including 29 dissolved embryos frozen on day 3, 80 frozen on day 4, and 39 frozen on day 5 - results were examined in terms of clinical pregnancy rates. In this study, across all three groups, no significant differences were observed in terms of patient age, the number of oocytes collected, infertility reasons, the number of embryos dissolved, transfer day, or the number of embryos transferred. According to the transfer day, the rates of clinical pregnancy and ongoing pregnancy were significantly higher for embryos frozen on day 4 and transferred on day 5. Significantly higher rates of pregnancy and live birth were determined during in vitro fertilization (IVF) treatment with the freezing of human embryos on day 4 and the transfer of those embryos on day 5.
本研究的目的是比较在胚胎发育第 3、4 和 5 天移植玻璃化和解冻的人类胚胎的临床妊娠率。在这项回顾性研究中，检查了 2016 年 1 月至 2018 年 12 月期间在土耳其安卡拉卫生科学大学古尔哈内培训和研究医院妇产科生殖医学中心冷冻和解冻的 148 个胚胎转移周期的结果。包括第 3 天解冻的 29 个胚胎、第 4 天解冻的 80 个胚胎和第 5 天解冻的 39 个胚胎在内的胚胎转移后，根据临床妊娠率检查了结果。在这项研究中，所有三组患者的年龄、采集的卵子数量、不孕原因、溶解的胚胎数量、转移日或转移的胚胎数量均无显著差异。根据转移日，第 4 天冷冻和第 5 天转移的胚胎的临床妊娠率和持续妊娠率显著更高。第 4 天冷冻人类胚胎和第 5 天转移这些胚胎的体外受精 (IVF) 治疗确定了更高的妊娠率和活产率。
