School of Biological Sciences and Biotechnology Graduate School, Chonnam National University, Gwangju 61186, Korea.
Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju 61186; Research Center of Ecomimetics, Chonnam National University, Gwangju 61186, Korea.
BMB Rep. 2020 Apr;53(4):181-190. doi: 10.5483/BMBRep.2020.53.4.019.
Protein phosphatase 4 (PP4), one of serine/threonine phosphatases, is involved in many critical cellular pathways, including DNA damage response (DNA repair, cell cycle regulation, and apoptosis), tumorigenesis, cell migration, immune response, stem cell development, glucose metabolism, and diabetes. PP4 has been steadily studied over the past decade about wide spectrum of physiological activities in cells. Given the many vital functions in cells, PP4 has great potential to develop into the finding of key working mechanisms and effective treatments for related diseases such as cancer and diabetes. In this review, we provide an overview of the cellular and molecular mechanisms by which PP4 impacts and also discuss the functional significance of it in cell health. [BMB Reports 2020; 53(4): 181-190].
蛋白磷酸酶 4（PP4）是一种丝氨酸/苏氨酸磷酸酶，参与许多关键的细胞途径，包括 DNA 损伤反应（DNA 修复、细胞周期调控和细胞凋亡）、肿瘤发生、细胞迁移、免疫反应、干细胞发育、葡萄糖代谢和糖尿病。在过去的十年中，人们一直在研究 PP4 在细胞中广泛的生理活性。鉴于其在细胞中的许多重要功能，PP4 很有潜力成为发现癌症和糖尿病等相关疾病关键工作机制和有效治疗方法的研究对象。在这篇综述中，我们概述了 PP4 影响细胞的细胞和分子机制，并讨论了其在细胞健康中的功能意义。[BMB 报告 2020;53(4):181-190]。
