Cornish J, Vanderwee M, Findon G, Miller T
Department of Medicine, University of Auckland, New Zealand.
Br J Exp Pathol. 1988 Dec;69(6):839-44.
The purpose of this study was to investigate unusual irregularities observed on the surface of kidneys from rats which had been treated with seven 'clinically effective doses' (25 or 50 mg/kg) of cyclosporin A (CsA). Surface corrugations were obvious on gross examination and were a universal finding in our study which involved greater than 50 rats. Examination by scanning electron microscopy (SEM) showed that the surface irregularities resulted from swollen peritubular capillaries adjacent to vacuolized and partially collapsed tubules at the cortical surface. The enlarged capillaries were associated with vascular congestion, and although peritubular capillary congestion has been recognized in CsA-treated patients, it has been difficult to determine whether this reaction is associated with drug toxicity or graft rejection. Our findings, indicating that peritubular capillary congestion in addition to vacuolization and collapse of subcapsular tubules is a drug-associated phenomenon, may help give a more accurate assessment of biopsy and autopsy material from CsA-treated patients and laboratory animals.
本研究的目的是调查用七种“临床有效剂量”（25或50毫克/千克）的环孢素A（CsA）处理过的大鼠肾脏表面观察到的异常不规则情况。大体检查时表面皱纹明显，这是我们这项涉及50多只大鼠的研究中的普遍发现。扫描电子显微镜（SEM）检查显示，表面不规则是由于皮质表面与空泡化且部分塌陷的肾小管相邻的肾小管周围毛细血管肿胀所致。扩大的毛细血管与血管充血有关，尽管在接受CsA治疗的患者中已认识到肾小管周围毛细血管充血，但一直难以确定这种反应是否与药物毒性或移植排斥有关。我们的研究结果表明，除了肾包膜下肾小管的空泡化和塌陷外，肾小管周围毛细血管充血是一种与药物相关的现象，这可能有助于对接受CsA治疗的患者和实验动物的活检和尸检材料进行更准确的评估。
