Thiel G, Hermle M, Brunner F P
Clin Nephrol. 1986;25 Suppl 1:S40-2.
The parenteral application of a cyclosporine A (CyA)-containing solution in high doses, 0.7 mg/kg/min, was associated with an acute reduction in renal blood-flow and a depression in creatinine clearance to approximately one half of control values. Exactly the same effect can be produced by the intravenous administration of the vehicle, cremophore, a polyoxyethylated castor-oil derivative. Although these observations are not of great clinical importance, since the doses of CyA used in man are much lower and the drug is generally taken orally, they are of considerable importance when studying the effects of CyA under experimental conditions. For the purpose of examining the influence of CyA on renal function, cremophore-containing solutions should be avoided.
以0.7毫克/千克/分钟的高剂量肠胃外应用含环孢素A（CyA）的溶液，会导致肾血流量急性减少，肌酐清除率降低至对照值的约一半。静脉注射溶媒聚氧乙烯蓖麻油衍生物聚氧乙烯蓖麻油（cremophore）可产生完全相同的效果。尽管这些观察结果在临床上并不十分重要，因为人类使用的CyA剂量要低得多且该药物通常口服，但在研究实验条件下CyA的作用时，它们具有相当重要的意义。为了研究CyA对肾功能的影响，应避免使用含聚氧乙烯蓖麻油的溶液。
