Bering Jamie, Hartmann Carlos, Asbury Kara, Vikram Holenarasipur R
Department of Internal Medicine, Mayo Clinic, Phoenix, Arizona, USA.
Division of Infectious Diseases, Mayo Clinic, Phoenix, Arizona, USA.
BMJ Case Rep. 2020 Mar 18;13(3):e231825. doi: 10.1136/bcr-2019-231825.
Herein we report a case of a 67-year-old man with chronic lymphocytic leukaemia who developed acute onset of fever and altered mental status while receiving ibrutinib therapy. He was eventually found to have meningitis. Timely diagnosis and appropriate antimicrobial therapy was associated with a favourable outcome. We describe challenges associated with appropriate identification of, and briefly review infections caused by sp. To our knowledge, this is the first case of invasive infection in the setting of ibrutinib therapy, and adds to the growing list of serious infections that have been associated with this agent.
在此，我们报告一例67岁慢性淋巴细胞白血病男性患者，在接受依鲁替尼治疗时出现急性发热和精神状态改变。最终发现他患有脑膜炎。及时诊断和适当的抗菌治疗带来了良好的结果。我们描述了与正确识别相关的挑战，并简要回顾了由某种细菌引起的感染。据我们所知，这是依鲁替尼治疗过程中发生侵袭性感染的首例病例，也增加了与该药物相关的严重感染的病例数量。
