School of Sports, Exericse and Rehabilitation Sciences, University of Birmingham, Birmingham, UK
Department of Nutritional Sciences, University of Surrey, Surrey, UK.
BMJ Open. 2020 Mar 18;10(3):e033824. doi: 10.1136/bmjopen-2019-033824.
Sarcopenia is a progressive loss in muscle mass, strength and function, the adverse consequences of which are severe, affecting quality of life and placing an increasing burden on social and healthcare systems. Vitamin D status is known to be associated with markers of sarcopenia, namely muscle mass, strength and function. Also, resistance exercise training (RET) is currently the only proven intervention to treat sarcopenia. However, very little data exist on the influence of combining the two interventions of vitamin D supplementation and resistance exercise training, although a recent systematic review provides tentative support for the current study's hypothesis that the combined intervention may further improve musculoskeletal function above exercise training alone. The aim of the present study is to determine whether vitamin D supplementation is any more effective in improving musculoskeletal function when combined with RET compared with exercise training alone in older adults.
This double-blinded randomised placebo-controlled trial will recruit a target of 127 eligible men and women aged ≥65 years living independently or in sheltered housing within the Birmingham area to two groups: (1) 6 months RET and placebo or (2) 6 months RET and 800 IU/d vitamin D. Measures of muscle power (Nottingham Power Rig), body composition (dual energy X-ray absorptiometry), muscle function (short physical performance battery, timed up and go), falls and fractures as events will be assessed. Assessments will take place at baseline and postintervention, with intermittent monitoring of bone turnover, calcium and vitamin D. The primary outcome will be lower limb extensor power output. Analyses of within-group changes and between-group differences in outcome measures are planned.
The EXVITD study has ethical approval granted by the Black Country National Health Service Research Ethics Committee (14/WM/1220). Results of this trial will be submitted for publication in peer-reviewed journals and presented at conferences. The study is being conducted according to the principles of the Declaration of Helsinki.NCT02467153; Post-results.
肌肉减少症是一种肌肉质量、力量和功能的进行性丧失，其不良后果严重，影响生活质量，并给社会和医疗保健系统带来越来越大的负担。维生素 D 状况已知与肌肉减少症的标志物有关，即肌肉质量、力量和功能。此外，抗阻运动训练（RET）是目前唯一被证实可用于治疗肌肉减少症的干预措施。然而，关于联合补充维生素 D 和抗阻运动训练这两种干预措施的影响的数据很少，尽管最近的系统评价为目前的研究假设提供了初步支持，即联合干预可能会进一步改善骨骼肌肉功能，超过单独运动训练。本研究的目的是确定在老年人中，与单独运动训练相比，补充维生素 D 是否更能有效改善骨骼肌肉功能。
这项双盲随机安慰剂对照试验将招募 127 名符合条件的年龄在 65 岁以上、居住在伯明翰地区独立或庇护性住房中的男性和女性，分为两组：（1）6 个月的 RET 和安慰剂或（2）6 个月的 RET 和 800 IU/d 维生素 D。肌肉力量（诺丁汉力量测试器）、身体成分（双能 X 射线吸收法）、肌肉功能（简短体能测试、计时起立行走）、跌倒和骨折等指标将进行评估。评估将在基线和干预后进行，并进行骨转换、钙和维生素 D 的间歇性监测。主要结局是下肢伸肌力量输出。计划对组内变化和组间差异进行分析。
EXVITD 研究已获得布莱克郡国家卫生服务研究伦理委员会（14/WM/1220）的伦理批准。该试验的结果将提交给同行评议期刊发表，并在会议上展示。该研究是根据《赫尔辛基宣言》的原则进行的。NCT02467153；试验后。
