Lundell K H, Bergman B, Svensson K, Hedner T
Department of Pediatrics, Central Hospital, Jönköping, Sweden.
Biol Neonate. 1988;54(3):144-50. doi: 10.1159/000242845.
The effects of the beta 2-adrenergic-stimulating drug, terbutaline, were studied on fetal rabbit lung liquid (FLL) at gestational ages between 25 and 30 days. At delivery terbutaline reduced FLL in rabbit fetuses with a gestational age of 26-30 days. The most pronounced reduction of FLL was seen at 28 days. Terbutaline administration reduced the wet lung weight/body weight (WLW/BW) ratio at delivery in the 28- and 30-day-old rabbit pups. In the 26-day-old animals, beta 2-adrenergic stimulation had no significant effect on the WLW/BW ratio and at 25 days of gestational age the ratio was increased. After parturition, however, the difference in WLW/BW between the terbutaline and control animals, seen at birth, was attenuated and, at 60 min of postnatal age, the difference was no longer observed. Terbutaline decreased the adrenal content of noradrenaline and adrenaline most marked at 28 days of gestational age, but did not alter the adrenaline/noradrenaline ratio. Furthermore, adrenal dopamine was decreased after terbutaline, suggesting a decreased catecholamine synthesis. Our data show that a positive effect of terbutaline on FLL in rabbit pups was most marked during late but not early gestational age. beta 2-Adrenergic treatment may, however, reduce adrenal catecholamines.
研究了β2 - 肾上腺素能刺激药物特布他林对妊娠25至30天的胎兔肺液（FLL）的影响。分娩时，特布他林可降低妊娠26 - 30天兔胎儿的FLL。在28天时，FLL的降低最为明显。给予特布他林可降低28日龄和30日龄兔幼崽分娩时的湿肺重量/体重（WLW/BW）比值。在26日龄动物中，β2 - 肾上腺素能刺激对WLW/BW比值无显著影响，而在妊娠25天时该比值升高。然而，分娩后，出生时特布他林组与对照组动物之间WLW/BW的差异减弱，在出生后60分钟时，不再观察到差异。特布他林最显著降低了妊娠28天时肾上腺去甲肾上腺素和肾上腺素的含量，但未改变肾上腺素/去甲肾上腺素比值。此外，特布他林给药后肾上腺多巴胺减少，提示儿茶酚胺合成减少。我们的数据表明，特布他林对兔幼崽FLL的积极作用在妊娠晚期而非早期最为明显。然而，β2 - 肾上腺素能治疗可能会减少肾上腺儿茶酚胺。
