Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, 1025 E. 7th Street, Bloomington, IN, 47405, USA.
Department of Environmental and Occupational Health, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.
Cancer Causes Control. 2020 May;31(5):503-510. doi: 10.1007/s10552-020-01294-0. Epub 2020 Mar 19.
Evidence on the association between diabetes and risk of bladder cancer has been controversial. In addition, findings on the associations between duration of diabetes, diabetes treatment, and risk of bladder cancer have been inconsistent.
A total of 148,208 participants in Women's Health Initiative study were included. Information on diabetes status, diabetes duration, and treatment was collected both at baseline and during follow-up. Information on potential confounders including age, race/ethnicity, education, occupation, family history of cancer, smoking status, alcohol consumption, total physical activity, body mass index, and daily dietary intake were collected at baseline. Bladder cancer cases were collected and confirmed by a centralized review of pathology reports. Cox proportional hazard models with time-varying covariates were used to examine associations of diabetes status, duration of diabetes, and diabetes treatment with bladder cancer risk.
During a median follow-up of 18.5 years, 865 bladder cancer cases were identified. There were no significant associations of diabetes, duration of diabetes, or diabetes treatment with risk of bladder cancer. Participants with prevalent diabetes did not have significantly higher risk of bladder cancer compared with those without diabetes.
Diabetes was not significantly associated with risk of bladder cancer among postmenopausal women.
糖尿病与膀胱癌风险之间的关联证据一直存在争议。此外，关于糖尿病持续时间、糖尿病治疗与膀胱癌风险之间的关联的研究结果也不一致。
共有 148208 名参加妇女健康倡议研究的参与者被纳入研究。糖尿病状况、糖尿病持续时间和治疗信息均在基线和随访期间收集。在基线时收集了有关潜在混杂因素的信息，包括年龄、种族/民族、教育程度、职业、癌症家族史、吸烟状况、饮酒量、总身体活动量、体重指数和每日膳食摄入量。膀胱癌病例通过对病理报告的集中审查收集并确认。使用时变协变量的 Cox 比例风险模型来检查糖尿病状况、糖尿病持续时间和糖尿病治疗与膀胱癌风险之间的关联。
在中位随访 18.5 年期间，共发现 865 例膀胱癌病例。糖尿病、糖尿病持续时间或糖尿病治疗与膀胱癌风险之间没有显著关联。与没有糖尿病的参与者相比，患有糖尿病的参与者膀胱癌的风险没有显著升高。
在绝经后妇女中，糖尿病与膀胱癌风险之间无显著相关性。
