Shiraishi N, Aono K, Taguchi T
Department of Radiation Medicine, Okayama University Medical School, Japan.
Biol Neonate. 1988;54(3):173-80. doi: 10.1159/000242849.
The tissue copper contents were measured in mutant (hemizygous macular male and homozygous macular female), heterozygous macular female and normal mice. The copper content in kidney and small intestine from 7-day-old mutant and heterozygote were extremely high compared to normal mice, whereas the copper content in other tissues (liver, brain, spleen and serum) was low. Copper content in whole body of mutant mice was extremely low at three stages (18 days gestation, 1 day old, and 7 days old) compared to normal mice with the exception of the mutant fetus at 14 days of gestation. Renal copper contents in the mutant fetus at 18 days of gestation and in the 1-day-old mutant were not changed compared to normal mice, whereas that in 7- and 14-day-old mutant mice was significantly elevated. Hepatic copper content of the mutant mice was extremely low at all stages compared to normal mice. Copper therapy was applied to 7-day-old mutant mice. At 1 day after injection, hepatic copper content in the mutants had increased slightly in comparison with the normal control mice, whereas renal copper content was extremely increased. At 7 days after injection, hepatic copper content in the mutants was decreased greatly in comparison with normal control mice, whereas an increase in renal copper content had remained.
对突变体（半合子黄斑雄性和纯合子黄斑雌性）、杂合子黄斑雌性和正常小鼠的组织铜含量进行了测量。与正常小鼠相比，7日龄突变体和杂合子的肾脏和小肠中的铜含量极高，而其他组织（肝脏、大脑、脾脏和血清）中的铜含量较低。与正常小鼠相比，除妊娠14天的突变体胎儿外，突变体小鼠在三个阶段（妊娠18天、1日龄和7日龄）的全身铜含量极低。与正常小鼠相比，妊娠18天的突变体胎儿和1日龄突变体的肾脏铜含量没有变化，而7日龄和14日龄突变体小鼠的肾脏铜含量显著升高。与正常小鼠相比，突变体小鼠在所有阶段的肝脏铜含量都极低。对7日龄突变体小鼠进行了铜治疗。注射后1天，与正常对照小鼠相比，突变体的肝脏铜含量略有增加，而肾脏铜含量则极度增加。注射后7天，与正常对照小鼠相比，突变体的肝脏铜含量大幅下降，而肾脏铜含量仍保持增加。
