Shiraishi N, Taguchi T, Kinebuchi H
Department of Environmental and Occupational Health, Kochi Medical School, Japan.
Biol Trace Elem Res. 1993 May-Jun;37(2-3):179-86. doi: 10.1007/BF02783793.
To evaluate the role of lysosomes in copper-mediated hepatocellular injury, copper was administered, sc, to both normal and macular mutant mice at doses of 4.5, 9.0, and 18 mg Cu/kg, and the subcellular distribution of copper has been investigated in the liver of normal and mutant mice 24 h after injection. The amount of copper in all fractions of copper-treated mutant mice was markedly lower than those in copper-treated normal mice, with the exception of microsomal fraction. However, there were no distinct differences in the proportion of copper in subcellular fractions between normal and mutant mice.
为评估溶酶体在铜介导的肝细胞损伤中的作用，将铜以4.5、9.0和18 mg Cu/kg的剂量皮下注射给正常小鼠和黄斑突变小鼠，并在注射后24小时研究了正常小鼠和突变小鼠肝脏中铜的亚细胞分布。除微粒体部分外，铜处理的突变小鼠所有组分中的铜含量均明显低于铜处理的正常小鼠。然而，正常小鼠和突变小鼠亚细胞组分中铜的比例没有明显差异。
