过表达EZHIP的组蛋白H3野生型弥漫性中线胶质瘤/间叶性胶质瘤在PRC2抑制作用下扩展了超出H3-K27M突变的弥漫性中线胶质瘤谱。 - Suppr

Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation.

作者信息

Castel David, Kergrohen Thomas, Tauziède-Espariat Arnault, Mackay Alan, Ghermaoui Samia, Lechapt Emmanuèle, Pfister Stefan M, Kramm Christof M, Boddaert Nathalie, Blauwblomme Thomas, Puget Stéphanie, Beccaria Kévin, Jones Chris, Jones David T W, Varlet Pascale, Grill Jacques, Debily Marie-Anne

机构信息

Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, 114 rue Édouard Vaillant, Villejuif, 94800, France.

Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

出版信息

Acta Neuropathol. 2020 Jun;139(6):1109-1113. doi: 10.1007/s00401-020-02142-w. Epub 2020 Mar 19.

DOI:10.1007/s00401-020-02142-w

PMID:32193787

Abstract

摘要

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Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation.过表达EZHIP的组蛋白H3野生型弥漫性中线胶质瘤/间叶性胶质瘤在PRC2抑制作用下扩展了超出H3-K27M突变的弥漫性中线胶质瘤谱。

Acta Neuropathol. 2020 Jun;139(6):1109-1113. doi: 10.1007/s00401-020-02142-w. Epub 2020 Mar 19.

Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location.弥漫性中线胶质瘤，H3 K27M 突变的转录组和表观遗传分析根据突变的组蛋白 H3 的类型而不是幕上或幕下位置对两个亚组进行区分。

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An integrative radiological, histopathological and molecular analysis of pediatric pontine histone-wildtype glioma with MYCN amplification (HGG-MYCN).小儿脑桥组蛋白野生型伴MYCN扩增的胶质瘤（HGG-MYCN）的综合放射学、组织病理学和分子分析

Acta Neuropathol Commun. 2019 Jun 10;7(1):87. doi: 10.1186/s40478-019-0738-y.

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.PFA 室管膜瘤相关蛋白 EZHIP 通过类似于 H3 K27M 的机制抑制 PRC2 活性。

Nat Commun. 2019 May 13;10(1):2146. doi: 10.1038/s41467-019-09981-6.

Acta Neuropathol Commun. 2018 Nov 5;6(1):117. doi: 10.1186/s40478-018-0614-1.

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.后颅窝 A 组（PFA）室管膜瘤中的分子异质性和 CXorf67 改变。

Acta Neuropathol. 2018 Aug;136(2):211-226. doi: 10.1007/s00401-018-1877-0. Epub 2018 Jun 16.

DNA methylation-based classification of central nervous system tumours.基于 DNA 甲基化的中枢神经系统肿瘤分类。

Nature. 2018 Mar 22;555(7697):469-474. doi: 10.1038/nature26000. Epub 2018 Mar 14.

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Eur J Cancer. 2016 Sep;65:91-101. doi: 10.1016/j.ejca.2016.06.009. Epub 2016 Jul 29.

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.2016 年世界卫生组织中枢神经系统肿瘤分类：概述。

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Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation.

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