Wang Lijing, Zhao Hongjun, Zhang Lemeng, Luo Hui, Chen Qiong, Zuo Xiaoxia
Department of Gerontology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Oncol Lett. 2020 Mar;19(3):2115-2122. doi: 10.3892/ol.2020.11318. Epub 2020 Jan 17.
Chronic obstructive pulmonary disease (COPD) and squamous cell lung carcinoma (SCC) are smoking-related diseases. However, the connection between the two is poorly understood. Microarray gene expression profiles in bronchial epithelium from patients with SCC with or without COPD were downloaded from the Gene Expression Omnibus repository. Differentially expressed genes associated with COPD and SCC were identified and visualized using the Advanced Network Merger module in Cytoscape. COPD-associated genes in SCC progression were further identified using the BisoGenet plug-in in Cytoscape. The genetic interaction network was predicted using the Network Analysis function. Heat shock protein 90 α family class A member 1 (), adrenoceptor β2 (), transducin β like 1 X-linked receptor 1 () and heat shock protein family B (small) member 1 () were identified to be differentially expressed in SCC and COPD cases. The overall survival rate associated with the gene signatures was investigated using clinical samples from patients with SCC and COPD from the PROGgene database. The results suggest that the pathogenesis of SCC caused by COPD is regulated by and . These genes may serve as potential therapeutic targets for the treatment of patients with COPD-related SCC.
慢性阻塞性肺疾病（COPD）和肺鳞状细胞癌（SCC）是与吸烟相关的疾病。然而，二者之间的联系却鲜为人知。从基因表达综合数据库下载了患有或未患有COPD的SCC患者支气管上皮中的微阵列基因表达谱。使用Cytoscape中的高级网络合并模块鉴定并可视化与COPD和SCC相关的差异表达基因。使用Cytoscape中的BisoGenet插件进一步鉴定SCC进展中与COPD相关的基因。使用网络分析功能预测遗传相互作用网络。已确定热休克蛋白90α家族A类成员1（）、肾上腺素能受体β2（）、转导素β样1 X连锁受体1（）和热休克蛋白家族B（小）成员1（）在SCC和COPD病例中差异表达。使用来自PROGgene数据库的SCC和COPD患者的临床样本研究了与基因特征相关的总生存率。结果表明，COPD导致的SCC发病机制受和调控。这些基因可能成为治疗COPD相关SCC患者的潜在治疗靶点。
