Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Theranostics. 2020 Jan 20;10(6):2453-2462. doi: 10.7150/thno.42981. eCollection 2020.
Manganese-based nanomaterials have piqued great interest in cancer nanotheranostics, owing to their excellent physicochemical properties. Here we report a facile wet-chemical synthesis of size-controllable, biodegradable, and metastable γ-phase manganese sulfide nanotheranostics, which is employed for tumor pH-responsive traceable gas therapy primed chemodynamic therapy (CDT), using bovine serum albumin (BSA) as a biological template (The final product was denoted as MnS@BSA). The as-prepared MnS@BSA can be degraded in response to the mildly acidic tumor microenvironment, releasing hydrogen sulfide (HS) for gas therapy and manganese ions for magnetic resonance imaging (MRI) and CDT. experiments validated the pH-responsiveness of MnS@BSA at pH 6.8 and both HS gas and •OH radicals were detected during its degradation. experiments showed efficiently tumor turn-on -weighted MRI, significantly suppressed tumor growth and greatly prolonged survival of tumor-bearing mice following intravenous administration of MnS@BSA. Our findings indicated that MnS@BSA nanotheranostics hold great potential for traceable HS gas therapy primed CDT of cancer.
基于锰的纳米材料因其优异的物理化学性质而在癌症纳米治疗学中引起了极大的兴趣。在这里，我们报告了一种简便的湿化学合成方法，可制备尺寸可控、可生物降解和亚稳态 γ 相硫化锰纳米治疗剂，用于肿瘤 pH 响应性可追踪气体治疗引发的化学动力学治疗（CDT），使用牛血清白蛋白（BSA）作为生物模板（最终产物表示为 MnS@BSA）。所制备的 MnS@BSA 可以响应轻度酸性的肿瘤微环境而降解，释放硫化氢（HS）进行气体治疗，并释放锰离子进行磁共振成像（MRI）和 CDT。实验验证了 MnS@BSA 在 pH 6.8 时的 pH 响应性，并且在其降解过程中检测到 HS 气体和•OH 自由基。实验表明，静脉注射 MnS@BSA 后，肿瘤的开启加权 MRI 效果显著，肿瘤生长得到明显抑制，荷瘤小鼠的存活时间大大延长。我们的研究结果表明，MnS@BSA 纳米治疗剂在可追踪的 HS 气体治疗引发的癌症 CDT 中具有很大的潜力。
