cullin-5的功能与特性，一种癌症的潜在治疗靶点。
The functions and properties of cullin-5, a potential therapeutic target for cancers.
作者信息
Gao Feng, Fan Yimin, Zhou Bolun, Guo Weihua, Jiang Xingjun, Shi Jing, Ren Caiping
机构信息
Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University 87 Xiangya Road, Kaifu District, Changsha 410008, China.
Cancer Research Institute, Collaborative Innovation Center for Cancer Medicine, School of Basic Medical Science, Central South University Changsha, Hunan, China.
出版信息
Am J Transl Res. 2020 Feb 15;12(2):618-632. eCollection 2020.
Abstract
Cullin-5 (CUL5), a scaffold protein in active cullin-RING ubiquitin ligase (CRL) complexes, is a member of the cullin family of proteins. The CUL5-type ubiquitin ligase can target multiple proteins involved in ubiquitination and proteasome degradation. CUL5 plays positive roles in regulating cell growth, proliferation and physiological and other processes in the human body. It has been found that the expression of CUL5 is significantly downregulated in various cancer cells, which affects the course of the cancers. Here, we reviewed the current data on the expression and role of CUL5 in both normal and cancer cells, its possible mechanisms, and its potential as a therapeutic target for cancers.
摘要
Cullin-5（CUL5）是活性cullin-RING泛素连接酶（CRL）复合物中的一种支架蛋白，是cullin蛋白家族的成员。CUL5型泛素连接酶可以靶向多种参与泛素化和蛋白酶体降解的蛋白质。CUL5在调节细胞生长、增殖以及人体生理等过程中发挥着积极作用。研究发现，CUL5在各种癌细胞中的表达显著下调，这影响了癌症的进程。在此，我们综述了目前关于CUL5在正常细胞和癌细胞中的表达及作用、其可能的机制以及其作为癌症治疗靶点的潜力的相关数据。
相似文献
1
The functions and properties of cullin-5, a potential therapeutic target for cancers.cullin-5的功能与特性，一种癌症的潜在治疗靶点。
Am J Transl Res. 2020 Feb 15;12(2):618-632. eCollection 2020.
2
Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.Cullin-5是一种泛素连接酶支架蛋白，在子宫内膜腺癌中显著低表达，并且是miR-182的一个靶点。
Oncol Rep. 2016 Apr;35(4):2461-5. doi: 10.3892/or.2016.4605. Epub 2016 Feb 1.
3
The role of cullin 5-containing ubiquitin ligases.含cullin 5的泛素连接酶的作用。
Cell Div. 2016 Mar 9;11:1. doi: 10.1186/s13008-016-0016-3. eCollection 2016.
4
Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G.灵长类慢病毒病毒体感染性因子是通过HCCH基序与cullin 5-E3连接酶组装以抑制载脂蛋白B mRNA编辑酶催化多肽样3G的底物受体。
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11444-9. doi: 10.1073/pnas.0502440102. Epub 2005 Aug 2.
5
Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases.轮状病毒NSP1与E3泛素连接酶的Cullin RING连接酶家族的组分相关联。
J Virol. 2016 Jun 10;90(13):6036-48. doi: 10.1128/JVI.00704-16. Print 2016 Jul 1.
6
Deregulation of the COP9 signalosome-cullin-RING ubiquitin-ligase pathway: mechanisms and roles in urological cancers.COP9 信号osome-cullin-RING 泛素连接酶途径的失调：在泌尿系统癌症中的机制和作用。
Int J Biochem Cell Biol. 2013 Jul;45(7):1327-37. doi: 10.1016/j.biocel.2013.03.023. Epub 2013 Apr 10.
7
The role of cullin proteins in gastric cancer.cullin蛋白在胃癌中的作用。
Tumour Biol. 2016 Jan;37(1):29-37. doi: 10.1007/s13277-015-4154-z. Epub 2015 Oct 15.
8
Using the E4orf6-Based E3 Ubiquitin Ligase as a Tool To Analyze the Evolution of Adenoviruses.使用基于E4orf6的E3泛素连接酶作为工具来分析腺病毒的进化。
J Virol. 2016 Jul 27;90(16):7350-7367. doi: 10.1128/JVI.00420-16. Print 2016 Aug 15.
9
Identification of a Conserved Interface of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Vifs with Cullin 5.1型人类免疫缺陷病毒和猫免疫缺陷病毒Vif与Cullin 5保守界面的鉴定
J Virol. 2018 Feb 26;92(6). doi: 10.1128/JVI.01697-17. Print 2018 Mar 15.
10
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions.基于Cullin 2的E3泛素连接酶的结构、调控及其生物学功能。
Cell Div. 2016 May 23;11:7. doi: 10.1186/s13008-016-0020-7. eCollection 2016.
引用本文的文献
1
Analysis of cullin family genes in rectal adenocarcinoma: expression, prognostic significance, and therapeutic implications.直肠癌中cullin家族基因的分析：表达、预后意义及治疗启示
Am J Transl Res. 2025 May 15;17(5):3842-3861. doi: 10.62347/UNVS8140. eCollection 2025.
2
The Role of Ubiquitin-Proteasome System (UPS) in Asthma Pathology.泛素-蛋白酶体系统（UPS）在哮喘病理中的作用。
J Asthma Allergy. 2025 Mar 1;18:307-330. doi: 10.2147/JAA.S490039. eCollection 2025.
3
Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway.Cullin-5缺陷可能通过调节JAK/STAT信号通路促进嵌合抗原受体T细胞的效应功能。
Nat Commun. 2024 Dec 10;15(1):10376. doi: 10.1038/s41467-024-54794-x.
4
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.诱导多能干细胞衍生神经元中的CRISPR筛选揭示了tau蛋白稳态的原理。
bioRxiv. 2024 Nov 4:2023.06.16.545386. doi: 10.1101/2023.06.16.545386.
5
Cullin-5 deficiency orchestrates the tumor microenvironment to promote mammary tumor development through CREB1-CCL2 signaling.Cullin-5 缺乏通过 CREB1-CCL2 信号调控肿瘤微环境促进乳腺肿瘤发生。
Sci Adv. 2023 Jan 20;9(3):eabq1395. doi: 10.1126/sciadv.abq1395.
6
How GRAIL controls Treg function to maintain self-tolerance.GRAIL 如何控制 Treg 功能以维持自身耐受。
Front Immunol. 2022 Dec 8;13:1046631. doi: 10.3389/fimmu.2022.1046631. eCollection 2022.
7
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.Cul5介导牛磺酸刺激的小鼠乳腺上皮细胞mTOR mRNA表达及增殖。
Amino Acids. 2023 Feb;55(2):243-252. doi: 10.1007/s00726-022-03222-9. Epub 2022 Nov 30.
8
A Comprehensive Review of Biological Roles and Interactions of Cullin-5 Protein.Cullin-5蛋白的生物学作用及相互作用的综合综述
ACS Omega. 2022 Feb 11;7(7):5615-5624. doi: 10.1021/acsomega.1c06890. eCollection 2022 Feb 22.
9
Cullin3 (CUL3) suppresses proliferation, migration and phenotypic transformation of PDGF-BB-stimulated vascular smooth muscle cells and mitigates inflammatory response by repressing Hedgehog signaling pathway.Cullin3（CUL3）通过抑制 Hedgehog 信号通路来抑制 PDGF-BB 刺激的血管平滑肌细胞的增殖、迁移和表型转化，并减轻炎症反应。
Bioengineered. 2021 Dec;12(2):9463-9472. doi: 10.1080/21655979.2021.1995572.
10
Cullin-5 (CUL5) as a potential prognostic marker in a pan-cancer analysis of human tumors.Cullin-5 (CUL5) 作为人类肿瘤泛癌分析中的一个潜在预后标志物。
Bioengineered. 2021 Dec;12(1):5348-5360. doi: 10.1080/21655979.2021.1940042.
本文引用的文献
1
Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma.周期素依赖性激酶 5 作为透明细胞肾细胞癌的一种有前途的生物标志物。
BMC Cancer. 2019 Jul 16;19(1):698. doi: 10.1186/s12885-019-5905-9.
2
A potential significance of circ_0024169 down regulation in angiosarcoma tissue.环状RNA_0024169在血管肉瘤组织中下调的潜在意义。
Intractable Rare Dis Res. 2019 May;8(2):129-133. doi: 10.5582/irdr.2019.01034.
3
HSP90 Molecular Chaperones, Metabolic Rewiring, and Epigenetics: Impact on Tumor Progression and Perspective for Anticancer Therapy.热休克蛋白 90 分子伴侣、代谢重编程和表观遗传学：对肿瘤进展的影响及抗肿瘤治疗的展望。
Cells. 2019 Jun 3;8(6):532. doi: 10.3390/cells8060532.
4
MicroRNA-27a regulates the proliferation, chemosensitivity and invasion of human ovarian cancer cell lines by targeting Cullin 5.MicroRNA-27a 通过靶向 Cullin 5 调节人卵巢癌细胞系的增殖、化疗敏感性和侵袭。
Arch Biochem Biophys. 2019 Jun 15;668:9-15. doi: 10.1016/j.abb.2019.04.009. Epub 2019 Apr 29.
5
Gold nanoparticles loaded with cullin-5 DNA increase sensitivity to 17-AAG in cullin-5 deficient breast cancer cells.载金纳米颗粒的 cullin-5 DNA 增加了 cullin-5 缺陷型乳腺癌细胞对 17-AAG 的敏感性。
Int J Pharm. 2019 Jun 10;564:281-292. doi: 10.1016/j.ijpharm.2019.04.022. Epub 2019 Apr 16.
6
Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1.Cullin5 缺失通过稳定整合素 β1 促进小细胞肺癌转移。
J Clin Invest. 2019 Mar 1;129(3):972-987. doi: 10.1172/JCI122779. Epub 2019 Jan 28.
7
Cullin 5 is a novel candidate tumor suppressor in renal cell carcinoma involved in the maintenance of genome stability.Cullin 5是肾细胞癌中一种新型的候选肿瘤抑制因子，参与基因组稳定性的维持。
Oncogenesis. 2019 Jan 9;8(1):4. doi: 10.1038/s41389-018-0110-2.
8
Cancer statistics, 2019.癌症统计数据，2019 年。
CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.
9
ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer.内质网应激介导的恶性抑制作用被 ERp29 抵消，并促进结直肠癌的转移。
Oncol Rep. 2019 Mar;41(3):1603-1615. doi: 10.3892/or.2018.6943. Epub 2018 Dec 19.
10
ANKRD9 is associated with tumor suppression as a substrate receptor subunit of ubiquitin ligase.ANKRD9 作为泛素连接酶的底物受体亚基与肿瘤抑制有关。
Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3145-3153. doi: 10.1016/j.bbadis.2018.07.001. Epub 2018 Jul 3.
Zotero 插件