Ancelin Marie-Laure, Carriere Isabelle, Artero Sylvaine, Maller Jerome J, Meslin Chantal, Dupuy Anne-Marie, Ritchie Karen, Ryan Joanne, Chaudieu Isabelle
Neuropsychiatry: Epidemiological and Clinical Research, INSERM, University of Montpellier, Montpellier, France.
Monash Alfred Psychiatry Research Centre, Central Clinical School, Monash University and the Alfred Hospital, Melbourne, Australia.
Eur J Psychotraumatol. 2020 Mar 4;11(1):1733247. doi: 10.1080/20008198.2020.1733247. eCollection 2020.
: Findings on structural brain alterations following trauma are inconsistent due probably to heterogeneity in imaging studies and population, clinical presentations, genetic vulnerability, and selection of controls. This study examines whether trauma and re-experiencing symptoms are associated with specific alterations in grey matter volumes and if this varies according to genotype. : Structural MRI was used to acquire anatomical scans from 377 community-dwelling older adults. Quantitative regional estimates of 22 subregional volumes were derived using FreeSurfer software. Lifetime trauma was assessed using the validated Watson's PTSD inventory, which evaluates the most severe trauma experienced according to DSM criteria. Analyses adjusted for age, sex, total brain volume, head injury, and comorbidities. : Of the 212 participants reporting lifetime trauma, 35.4% reported re-experiencing symptoms and for 1.9%, this was severe enough to meet criteria for full threshold PTSD. In participants with the genotype only, re-experiencing symptoms were associated with smaller volumes in middle and superior temporal, frontal (lateral orbital, rostral and caudal middle) and parietal (precuneus, inferior and superior) regions. The trauma-exposed participants without re-experiencing symptoms were not significantly different from the non-trauma-exposed participants except for smaller precuneus and superior parietal region in traumatized participants and a larger amygdala in traumatized women specifically. : In the non-clinical sample, lifetime trauma and re-experiencing symptoms were associated with smaller volume in prefrontal, temporal and parietal cortex subregions, and this varied according to serotonergic genetic vulnerability, individuals being most susceptible.
创伤后大脑结构改变的研究结果不一致，这可能是由于成像研究、人群、临床表现、遗传易感性和对照选择的异质性所致。本研究探讨创伤和重现症状是否与灰质体积的特定改变相关，以及这种相关性是否因基因型而异。：使用结构磁共振成像（MRI）对377名居住在社区的老年人进行解剖扫描。使用FreeSurfer软件得出22个亚区域体积的定量区域估计值。使用经过验证的沃森创伤后应激障碍（PTSD）量表评估终生创伤，该量表根据《精神疾病诊断与统计手册》（DSM）标准评估经历的最严重创伤。分析对年龄、性别、全脑体积、头部损伤和合并症进行了校正。：在212名报告有终生创伤的参与者中，35.4%报告有重现症状，1.9%的症状严重到符合完全阈值PTSD的标准。仅在具有该基因型的参与者中，重现症状与颞中、颞上、额叶（外侧眶部、嘴侧和尾侧中部）和顶叶（楔前叶、下顶叶和上顶叶）区域体积较小有关。没有重现症状的创伤暴露参与者与未暴露于创伤的参与者没有显著差异，只是创伤参与者的楔前叶和上顶叶区域较小，特别是创伤女性的杏仁核较大。：在非临床样本中，终生创伤和重现症状与前额叶、颞叶和顶叶皮质亚区域体积较小有关，并且这种相关性因血清素能遗传易感性而异，个体最为易感。
