Mill A J, Harrison K G
Health Physics Research Section, Berkeley Nuclear Laboratories, CEGB, Gloucestershire.
Br J Radiol. 1988 Dec;61(732):1147-54. doi: 10.1259/0007-1285-61-732-1147.
Monte-Carlo computer codes have been used to estimate the distribution of doses to borated and unborated tissues in head-sized phantoms when exposed to beams of 2 keV and 24 keV neutrons. For the application of such beams to boron neutron capture therapy (BNCT) these calculations show the superiority of 2 keV neutrons over 24 keV neutrons and the importance of using large-area beams. A 24 keV neutron beam has been used to irradiate HeLa cell cultures in vitro, with and without the addition of 10B, at various depths within a narrow polyethylene phantom. Survival data obtained from these experiments have been used to estimate depth-damage profiles for normal (unboronated) and tumour (boronated) brain tissues when exposed to 24 keV neutrons. A good differential between damage to normal and tumorous tissue is obtained under suitable irradiation conditions. Although lower-energy neutrons are probably preferable, these results demonstrate the possibility of using beams of 24 keV neutrons for the BNCT of brain tumours.
蒙特卡罗计算机代码已被用于估计头部尺寸模型中含硼和不含硼组织在受到2 keV和24 keV中子束照射时的剂量分布。对于将此类中子束应用于硼中子俘获疗法（BNCT），这些计算表明2 keV中子优于24 keV中子，以及使用大面积中子束的重要性。已使用24 keV中子束在窄聚乙烯模型内的不同深度对添加和未添加10B的体外HeLa细胞培养物进行辐照。从这些实验获得的存活数据已被用于估计正常（未含硼）和肿瘤（含硼）脑组织在受到24 keV中子照射时的深度损伤剖面。在合适的辐照条件下，正常组织和肿瘤组织的损伤之间有良好的差异。尽管较低能量的中子可能更可取，但这些结果证明了使用24 keV中子束进行脑肿瘤BNCT的可能性。
