Fuster B, Tormo N, Salvador C, Gimeno C
Consorcio Hospital General Universitario de Valencia, University of Valencia, Valencia, Spain.
Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain.
New Microbes New Infect. 2020 Feb 16;34:100660. doi: 10.1016/j.nmni.2020.100660. eCollection 2020 Mar.
is one of the most common hospital-acquired Gram-negative pathogens. During the last decade, the emergence of strains with reduced susceptibility or resistance to carbapenems is becoming a therapeutic challenge. This study takes place after the isolation of 14 strains of carbapenem-resistant with similar susceptibility patterns and carriage of OXA-48 and NDM-1 carbapenemases genes. Fourteen patients were found to be colonized (faecal carriage) and/or infected by two different clones of carbapenemase-coproducing during a 1-year period of time. Some of the patients had shared a hospital ward and continued to be colonized several months after the outbreak.
是最常见的医院获得性革兰氏阴性病原体之一。在过去十年中，对碳青霉烯类药物敏感性降低或耐药的菌株的出现正成为一个治疗挑战。本研究是在分离出14株具有相似药敏模式且携带OXA - 48和NDM - 1碳青霉烯酶基因的耐碳青霉烯菌株之后进行的。在1年的时间里，发现14名患者被两种不同的产碳青霉烯酶克隆株定植（粪便携带）和/或感染。一些患者曾共用一个医院病房，并且在疫情爆发后数月仍持续被定植。
