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cGAS介导的免疫反应调控与免疫治疗

Regulation of cGAS-Mediated Immune Responses and Immunotherapy.

作者信息

Saeed Abdullah F U H, Ruan Xinglin, Guan Hongxin, Su Jingqian, Ouyang Songying

机构信息

The Key Laboratory of Innate Immune Biology of Fujian Province Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation Biomedical Research Center of South China Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education College of Life Sciences Fujian Normal University Fuzhou 350117 China.

Fujian Key Laboratory of Special Marine Bio-resources Sustainable Utilization The Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Product of State Oceanic Administration College of Life Sciences Fujian Normal University Fuzhou 350117 China.

出版信息

Adv Sci (Weinh). 2020 Feb 6;7(6):1902599. doi: 10.1002/advs.201902599. eCollection 2020 Mar.

DOI:10.1002/advs.201902599
PMID:32195086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7080523/
Abstract

Early detection of infectious nucleic acids released from invading pathogens by the innate immune system is critical for immune defense. Detection of these nucleic acids by host immune sensors and regulation of DNA sensing pathways have been significant interests in the past years. Here, current understandings of evolutionarily conserved DNA sensing cyclic GMP-AMP (cGAMP) synthase (cGAS) are highlighted. Precise activation and tight regulation of cGAS are vital in appropriate innate immune responses, senescence, tumorigenesis and immunotherapy, and autoimmunity. Hence, substantial insights into cytosolic DNA sensing and immunotherapy of indispensable cytosolic sensors have been detailed to extend limited knowledge available thus far. This Review offers a critical, in-depth understanding of cGAS regulation, cytosolic DNA sensing, and currently established therapeutic approaches of essential cytosolic immune agents for improved human health.

摘要

先天免疫系统早期检测入侵病原体释放的感染性核酸对于免疫防御至关重要。过去几年，宿主免疫传感器对这些核酸的检测以及DNA传感途径的调节一直是研究的热点。在此，重点介绍了目前对进化上保守的DNA传感环状GMP-AMP（cGAMP）合酶（cGAS）的认识。cGAS的精确激活和严格调控在适当的先天免疫反应、衰老、肿瘤发生、免疫治疗和自身免疫中至关重要。因此，已详细阐述了对胞质DNA传感和不可或缺的胞质传感器免疫治疗的大量见解，以扩展目前有限的相关知识。本综述对cGAS调节、胞质DNA传感以及目前已确立的重要胞质免疫因子治疗方法进行了批判性、深入的解读，以促进人类健康。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/686e6d11813b/ADVS-7-1902599-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/0783564592c2/ADVS-7-1902599-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/bd9f755e0d5f/ADVS-7-1902599-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/41fc6ced856a/ADVS-7-1902599-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/ef28c99206e4/ADVS-7-1902599-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/686e6d11813b/ADVS-7-1902599-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/0783564592c2/ADVS-7-1902599-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/bd9f755e0d5f/ADVS-7-1902599-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/41fc6ced856a/ADVS-7-1902599-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/ef28c99206e4/ADVS-7-1902599-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5faa/7080523/686e6d11813b/ADVS-7-1902599-g005.jpg

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