The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, 430081, China.
Macromol Rapid Commun. 2020 May;41(9):e2000022. doi: 10.1002/marc.202000022. Epub 2020 Mar 20.
Smart DNA nanostructures have found potential application in material science and biomedicine. Most building blocks are DNA amphiphiles covalently synthesized from DNA and hydrophobic molecules. Here, the noncovalent approach based on the host-guest interaction between cucurbit[7]uril (CB[7]) and two hydrophobic guests with different topologies is utilized to modularly construct supramolecular DNA amphiphiles including DNA-CB[7]/ferrocene derivative and DNA-CB[7]/adamantine derivative. Both of the supramolecular DNA amphiphiles assemble into uniform spherical micelles, which can encapsulate hydrophobic Nile Red molecules and anchor gold nanoparticles through DNA hybridization. In addition, 1-adamantanamine hydrochloride, a competitive guest with a strong binding constant with CB[7], induces the dissociation of DNA-CB[7]/ferrocene derivative micelles. More importantly, the redox properties of ferrocene induce reversible morphology changes between the spherical micelles and the dissociated state. These stimuli-responsive DNA supra-amphiphilic micelles, as novel vehicles, expand the family of smart DNA nanostructures.
智能 DNA 纳米结构在材料科学和生物医药领域有潜在的应用。大多数构建模块是通过 DNA 和疏水分子共价合成的 DNA 两亲物。在这里，基于葫芦[7]脲（CB[7]）与两种具有不同拓扑结构的疏水分子之间的主客体相互作用的非共价方法被用于模块化构建超分子 DNA 两亲物，包括 DNA-CB[7]/ 二茂铁衍生物和 DNA-CB[7]/ 金刚烷衍生物。这两种超分子 DNA 两亲物都组装成均匀的球形胶束，可以通过 DNA 杂交封装疏水性尼罗红分子和锚定金纳米粒子。此外，盐酸 1-金刚烷胺是一种与 CB[7]具有强结合常数的竞争性客体，诱导 DNA-CB[7]/ 二茂铁衍生物胶束的解离。更重要的是，二茂铁的氧化还原性质诱导了球形胶束和离解状态之间的可逆形态变化。这些响应性 DNA 超两亲性胶束作为新型载体，扩展了智能 DNA 纳米结构的家族。
