Braun V
Naturwissenschaften. 1977 Mar;64(3):126-32. doi: 10.1007/BF00450570.
The resistance of mainly gram-negative bacteria against antibiotics is discussed with respect to new discoveries on the permeability barrier of the outer membrane. Proteins originally characterized as virus receptors have been found to be involved in the translocation of certain substrates across the membrane. Antibiotics can reach their target by the same "pores".
针对外膜通透性屏障的新发现,讨论了主要革兰氏阴性菌对抗生素的耐药性。最初被鉴定为病毒受体的蛋白质已被发现参与某些底物跨膜转运。抗生素可通过相同的“孔道”到达其靶点。