Kozieł Marta Justyna, Kowalska Karolina, Piastowska-Ciesielska Agnieszka Wanda
Medical University of Lodz, Department of Cell Culture and Genomic Analysis, Lodz 90-752, Poland.
Cancers (Basel). 2020 Mar 18;12(3):711. doi: 10.3390/cancers12030711.
Claudins are major integral proteins of tight junctions (TJs), the apical cell-cell adhesions that enable maintaining polarity of epithelial cells, their differentiation, and cell signaling. A number of studies have indicated that claudins might play a crucial role in both physiology and pathogenesis. Their tissue-specific expression was originally linked to the development of different types of cancer and triggered a hope to use them as diagnostic or prognostic markers. However, it seems that their expression is more complex than that, and undoubtedly, claudins participate in one of the most important molecular events in cells. This review summarizes the recent research evaluating the role of claudins in fertility and the most common endocrine-dependent cancers in the reproductive system and highlights the crucial role of claudins both in human fertility and the most common cancers.
紧密连接蛋白是紧密连接（TJs）的主要整合蛋白，紧密连接是顶端细胞间黏附结构，能够维持上皮细胞的极性、分化及细胞信号传导。多项研究表明，紧密连接蛋白可能在生理和发病机制中都发挥着关键作用。它们的组织特异性表达最初与不同类型癌症的发生发展相关，并引发了将其用作诊断或预后标志物的希望。然而，其表达似乎更为复杂，毫无疑问，紧密连接蛋白参与了细胞中最重要的分子事件之一。本综述总结了近期评估紧密连接蛋白在生殖力以及生殖系统中最常见的内分泌依赖性癌症中作用的研究，并强调了紧密连接蛋白在人类生殖力和最常见癌症中的关键作用。
