Department of Family Medicine, Pingtung Hospital, Ministry of Health and Welfare, Pingtung 90054, Taiwan.
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Int J Environ Res Public Health. 2020 Mar 18;17(6):1997. doi: 10.3390/ijerph17061997.
Oral health and dentition have been associated with cognitive ability and frailty, but an applicable screening tool has not yet been developed. This study aimed to establish risk prediction models for dementia and frailty. A sample of 2905 community-dwelling older adults aged ≥58 years using the Taiwan Longitudinal Study on Aging (TLSA) survey was adapted and analyzed for this study. Risk scores were estimated by stepwise logistic regression. In models adjusted for covariates, increased age, female sex, no dental prosthesis (adjusted Odds ratio [adjOR], 1.61; 95% confidence interval [CI], 1.11-2.35), diabetes mellitus, chronic kidney disease, and an increased Oral Health Impact Profile (OHIP)-7T Q3 score (adjOR, 1.33; 95% CI, 1.19-1.49) were all significantly associated with frailty. In addition to these factors, an inability to self-report height or weight (adjOR, 4.52; 95% CI, 3.52-5.81) and an increased OHIP-7T Q7 score (adjOR, 1.21; 95% CI, 1.06-1.37) were significantly associated with dementia. The cut-off points of the risk scores for frailty and dementia were 80 (sensitivity, 80.0%; specificity, 81.2%) and 77 (sensitivity, 83.4%; specificity, 71.5%), respectively. The findings highlighted a number of composite risk factors of frailty and dementia. Importantly, the developed prediction models were easily applicable to screen for frailty and dementia in communities or dental clinics.
口腔健康和牙齿状况与认知能力和虚弱有关，但尚未开发出适用的筛查工具。本研究旨在建立痴呆和虚弱的风险预测模型。本研究采用了来自台湾老龄化纵向研究（TLSA）调查的 2905 名年龄≥58 岁的社区居住老年人样本，并对其进行了适应性分析。通过逐步逻辑回归估计风险评分。在调整了协变量的模型中，年龄增长、女性、无义齿（调整后的优势比 [adjOR]，1.61；95%置信区间 [CI]，1.11-2.35）、糖尿病、慢性肾脏病和增加的口腔健康影响量表（OHIP）-7T Q3 评分（adjOR，1.33；95%CI，1.19-1.49）均与虚弱显著相关。除了这些因素外，无法自我报告身高或体重（adjOR，4.52；95%CI，3.52-5.81）和增加的 OHIP-7T Q7 评分（adjOR，1.21；95%CI，1.06-1.37）与痴呆也显著相关。虚弱和痴呆的风险评分的截止值分别为 80（敏感性，80.0%；特异性，81.2%）和 77（敏感性，83.4%；特异性，71.5%）。这些发现强调了虚弱和痴呆的一些综合风险因素。重要的是，开发的预测模型易于在社区或牙科诊所中用于筛查虚弱和痴呆。
