Faculty of Food Technology & Biotechnology, University of Zagreb, Pierottijeva 6, 10 000 Zagreb, Croatia.
Mar Drugs. 2020 Mar 18;18(3):168. doi: 10.3390/md18030168.
Over the years, brown algae bioactive polysaccharides laminarin, alginate and fucoidan have been isolated and used in functional foods, cosmeceutical and pharmaceutical industries. The extraction process of these polysaccharides includes several complex and time-consuming steps and the correct adjustment of extraction parameters (e.g., time, temperature, power, pressure, solvent and sample to solvent ratio) greatly influences the yield, physical, chemical and biochemical properties as well as their biological activities. This review includes the most recent conventional procedures for brown algae polysaccharides extraction along with advanced extraction techniques (microwave-assisted extraction, ultrasound assisted extraction, pressurized liquid extraction and enzymes assisted extraction) which can effectively improve extraction process. The influence of these extraction techniques and their individual parameters on yield, chemical structure and biological activities from the most current literature is discussed, along with their potential for commercial applications as bioactive compounds and drug delivery systems.
多年来，褐藻生物活性多糖岩藻依聚糖、褐藻酸盐和褐藻糖胶已被分离出来并用于功能食品、化妆品和制药行业。这些多糖的提取过程包括几个复杂且耗时的步骤，正确调整提取参数（例如时间、温度、功率、压力、溶剂和样品与溶剂的比例）会极大地影响产量、物理、化学和生化特性以及它们的生物活性。本综述包括褐藻多糖提取的最新常规方法以及先进的提取技术（微波辅助提取、超声辅助提取、加压液体提取和酶辅助提取），这些技术可以有效地改进提取过程。讨论了这些提取技术及其各个参数对文献中最新的产量、化学结构和生物活性的影响，以及它们作为生物活性化合物和药物传递系统的商业应用潜力。
