Department of Pharmaceutics, Hangzhou Third Hospital, Hangzhou, 310009, China.
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
J Nanobiotechnology. 2019 Jul 10;17(1):82. doi: 10.1186/s12951-019-0514-y.
Skin damages are defined as one of most common lesions people suffer from, some of wounds are notoriously difficult to eradicate such as chronic wounds and deep burns. Existing wound therapies have been proved to be inadequate and far from satisfactory. The cutting-edge nanotechnology offers an unprecedented opportunity to revolutionize and invent new therapies or boost the effectiveness of current medical treatments. In particular, the nano-drug delivery systems anchor bioactive molecules to applied area, sustain the drug release and explicitly enhance the therapeutic efficacies of drugs, thus making a fine figure in field relevant to skin regeneration. This review summarized and discussed the current nano-drug delivery systems holding pivotal potential for wound healing and skin regeneration, with a special emphasis on liposomes, polymeric nanoparticles, inorganic nanoparticles, lipid nanoparticles, nanofibrous structures and nanohydrogel.
皮肤损伤被定义为人们最常见的病变之一，有些伤口很难消除，如慢性伤口和深度烧伤。现有的伤口治疗方法已被证明是不够的，远不能令人满意。前沿的纳米技术为彻底改变和发明新的治疗方法或提高现有医疗的效果提供了前所未有的机会。特别是，纳米药物传递系统将生物活性分子固定在应用区域，维持药物释放，并明确增强药物的治疗效果，因此在皮肤再生相关领域表现出色。本综述总结和讨论了目前对伤口愈合和皮肤再生具有关键潜力的纳米药物传递系统，重点介绍了脂质体、聚合物纳米粒子、无机纳米粒子、脂质纳米粒子、纳米纤维结构和纳米水凝胶。
