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Diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma.

作者信息

Pratt Drew, Quezado Martha, Abdullaev Zied, Hawes Debra, Yang Fusheng, Garton Hugh J L, Judkins Alexander R, Mody Rajen, Chinnaiyan Arul, Aldape Kenneth, Koschmann Carl, Venneti Sriram

机构信息

Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan, 3520E MSRB 1, 1150 W. Medical Center, Ann Arbor, MI, 48109, USA.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

出版信息

Acta Neuropathol Commun. 2020 Mar 20;8(1):37. doi: 10.1186/s40478-020-00905-w.

DOI:10.1186/s40478-020-00905-w
PMID:32197665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7083001/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5485/7083001/d000e98d6547/40478_2020_905_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5485/7083001/1ed489bbf98e/40478_2020_905_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5485/7083001/d000e98d6547/40478_2020_905_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5485/7083001/1ed489bbf98e/40478_2020_905_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5485/7083001/d000e98d6547/40478_2020_905_Fig2_HTML.jpg

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本文引用的文献

1
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016.美国 2012-2016 年诊断的原发性脑和其他中枢神经系统肿瘤 CBTRUS 统计报告。
Neuro Oncol. 2019 Nov 1;21(Suppl 5):v1-v100. doi: 10.1093/neuonc/noz150.
2
CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.CATACOMB：一种内源性诱导基因，通过类似于 H3K27M 的机制拮抗多梳抑制复合物 2 的 H3K27 甲基化活性。
Sci Adv. 2019 Jul 3;5(7):eaax2887. doi: 10.1126/sciadv.aax2887. eCollection 2019 Jul.
3
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.
Brain Pathol. 2024 Jan;34(1):e13181. doi: 10.1111/bpa.13181. Epub 2023 Jun 18.
4
Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes.伴有 H3K27me3 缺失的野生型组蛋白 H3 弥漫中线胶质瘤是一种独特的实体，具有独特的 EGFR 或 ACVR1 突变和同源盒基因的差异甲基化。
Sci Rep. 2023 Mar 7;13(1):3775. doi: 10.1038/s41598-023-30395-4.
5
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways.H3K27M DMGs 和 PFA 室管膜瘤的常见分子特征映射到后脑发育途径。
Acta Neuropathol Commun. 2023 Feb 9;11(1):25. doi: 10.1186/s40478-023-01514-z.
6
H3K27me3 in Diffuse Midline Glioma and Epithelial Ovarian Cancer: Opposing Epigenetic Changes Leading to the Same Poor Outcomes.H3K27me3 在弥漫性中线胶质瘤和上皮性卵巢癌中的作用：相反的表观遗传变化导致相同的不良结局。
Cells. 2022 Oct 26;11(21):3376. doi: 10.3390/cells11213376.
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Posterior fossa ependymoma H3 K27-mutant: an integrated radiological and histomolecular tumor analysis.后颅窝室管膜瘤 H3 K27 突变型：综合影像学和组织分子肿瘤分析。
Acta Neuropathol Commun. 2022 Sep 14;10(1):137. doi: 10.1186/s40478-022-01442-4.
8
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Lab Invest. 2022 Jul;102(7):731-740. doi: 10.1038/s41374-022-00769-9. Epub 2022 Mar 24.
10
EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma.EZHIP：理解儿童后颅窝室管膜瘤的新拼图。
Acta Neuropathol. 2022 Jan;143(1):1-13. doi: 10.1007/s00401-021-02382-4. Epub 2021 Nov 11.
PFA 室管膜瘤相关蛋白 EZHIP 通过类似于 H3 K27M 的机制抑制 PRC2 活性。
Nat Commun. 2019 May 13;10(1):2146. doi: 10.1038/s41467-019-09981-6.
4
EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.EZHIP/CXorf67 模拟 K27M 突变的癌组蛋白，并作为侵袭性后颅窝室管膜瘤中 PRC2 功能的内在抑制剂发挥作用。
Neuro Oncol. 2019 Jul 11;21(7):878-889. doi: 10.1093/neuonc/noz058.
5
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.H3K27M 诱导 PRC2 介导的抑制性 H3K27me2/me3 染色质扩散缺陷，并对神经胶质瘤发生至关重要。
Nat Commun. 2019 Mar 19;10(1):1262. doi: 10.1038/s41467-019-09140-x.
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Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma.PRC2 抑制的多种模式在 H3K27M 型小儿脑胶质瘤中引发全基因组染色质改变。
Sci Adv. 2018 Oct 31;4(10):eaau5935. doi: 10.1126/sciadv.aau5935. eCollection 2018 Oct.
7
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.后颅窝 A 组（PFA）室管膜瘤中的分子异质性和 CXorf67 改变。
Acta Neuropathol. 2018 Aug;136(2):211-226. doi: 10.1007/s00401-018-1877-0. Epub 2018 Jun 16.
8
Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma.新诊断弥漫性内生桥脑胶质瘤患者手术活检的前瞻性可行性和安全性评估。
Neuro Oncol. 2018 Oct 9;20(11):1547-1555. doi: 10.1093/neuonc/noy070.
9
DNA methylation-based classification of central nervous system tumours.基于 DNA 甲基化的中枢神经系统肿瘤分类。
Nature. 2018 Mar 22;555(7697):469-474. doi: 10.1038/nature26000. Epub 2018 Mar 14.
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Integrative clinical genomics of metastatic cancer.转移性癌症的整合临床基因组学
Nature. 2017 Aug 17;548(7667):297-303. doi: 10.1038/nature23306. Epub 2017 Aug 2.