Department of Dermatology and Venereology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Department of Dermatology and Venereology, Haydarpasa Numune Research and Teaching Hospital, Istanbul, Istanbul, Turkey.
Clin Dermatol. 2020 Jan-Feb;38(1):86-93. doi: 10.1016/j.clindermatol.2019.10.016. Epub 2019 Oct 23.
Dermatologic changes occur in a variety of rheumatic diseases. Skin can be the initial site of involvement, thus providing important clues for an accurate diagnosis based on cutaneous findings. Dermatologic findings can also be an indicator of systemic involvement and prognostic outcome; however, many connective tissue disorders have a wide variety of cutaneous manifestations, with significant overlap between different diseases. These skin signs often precede systemic clinical manifestations. Careful attention to characteristic dermatologic findings in Behçet's disease, systemic lupus erythematosus, rheumatoid arthritis, and various vasculitis can provide prompt therapeutic approaches in the case of life-threatening complications of systemically involved rheumatologic diseases.
在各种风湿性疾病中都会出现皮肤改变。皮肤可以是最初受累的部位，因此基于皮肤表现提供了准确诊断的重要线索。皮肤表现也可以是系统受累和预后结果的指标；然而，许多结缔组织疾病具有广泛的皮肤表现，不同疾病之间存在显著重叠。这些皮肤征象通常先于全身临床表现。密切注意白塞病、系统性红斑狼疮、类风湿关节炎和各种血管炎的特征性皮肤表现，可以在涉及全身的风湿性疾病出现危及生命的并发症时提供及时的治疗方法。
