Altomonte L, Zoli A, Alessi F, Ghirlanda G, Greco A V, Magarò M
Minerva Med. 1985 Jul 14;76(28-29):1323-9.
The connective tissue disorders are a protean group of acquired diseases which have in common widespread immunologic and inflammatory alterations of connective tissue. The acquired connective tissue diseases generally include the following clinical entities: rheumatoid arthritis, systemic lupus erythematosus, polymyositis, polyarteritis nodosa, scleroderma, mixed connective tissue disease, Sjögren's and Behcet's sindromes. These entities have certain features in common which include sinovitis, pleuritis, myocarditis, endocarditis, pericarditis, peritonitis, vasculitis, myositis, changes in skin, alteration of connective tissue and nephritis. Gastrointestinal and hepatic involvement in connective tissue disorders are not the most important features, nevertheless appear almost regularly. Anorexia, nausea, vomiting, abdominal pain, malabsorption may affect patients suffering by rheumatoid arthritis, systemic lupus erythematosus and other collagenophaties. In some cases mesenteric vasculitis may cause intestinal ischemia which may result in bowel infarction, mucosal ulceration, hemorrhage, perforation. After an extensive review of the existing literature the Authors make an accurate evaluation of gastrointestinal and hepatic alterations in connective tissue diseases.
结缔组织疾病是一组多样的后天性疾病，其共同特征是结缔组织广泛的免疫和炎症改变。后天性结缔组织疾病通常包括以下临床病症：类风湿性关节炎、系统性红斑狼疮、多发性肌炎、结节性多动脉炎、硬皮病、混合性结缔组织病、干燥综合征和白塞综合征。这些病症具有某些共同特征，包括滑膜炎、胸膜炎、心肌炎、心内膜炎、心包炎、腹膜炎、血管炎、肌炎、皮肤变化、结缔组织改变和肾炎。结缔组织疾病累及胃肠道和肝脏并非最重要的特征，但几乎总会出现。厌食、恶心、呕吐、腹痛、吸收不良可能影响类风湿性关节炎、系统性红斑狼疮和其他胶原病患者。在某些情况下，肠系膜血管炎可能导致肠道缺血，进而可能导致肠梗死、黏膜溃疡、出血、穿孔。在广泛查阅现有文献后，作者对结缔组织疾病中的胃肠道和肝脏改变进行了准确评估。
