Department of Animal Science, Pennsylvania State University, University Park 16802.
Zinpro Corporation, Eden Prairie, MN 55344.
J Dairy Sci. 2020 May;103(5):4838-4845. doi: 10.3168/jds.2019-17949. Epub 2020 Mar 18.
Successful passive transfer of antibodies in neonatal calves can be achieved by feeding an adequate quantity and quality of maternal colostrum (MC) or colostrum replacer (CR). An alternative could be feeding low-quality maternal colostrum (LMC) with added IgG from a CR. The objective of this study was to determine if a commercial whey-based CR product containing low levels of casein (Premolac PLUS Bovine IgG; Zinpro Corporation, Eden Prairie, MN) fed to replace MC or supplement LMC could lead to adequate serum IgG levels and apparent efficiency of absorption (AEA) in neonatal dairy calves. Holstein calves (n = 20 per treatment) were separated from their dam after birth and randomly assigned to be fed 3.79 L of MC (106 g/L of IgG; 401 g of IgG fed), LMC (30 g/L IgG) supplemented with CR (41 g/L IgG; 154 g of IgG total fed; LMC-CR), or 1.3 L of 1 of 2 levels of CR (110 or 150 g of IgG fed; CR-110 or CR-150) within 1.5 h of birth. Colostrum was obtained from the first (MC) or second and third milkings (LMC) of cows from Pennsylvania State University dairy and pooled by source into large batches. Blood samples were taken from calves before colostrum feeding and 24 h after birth and were analyzed for serum total protein, total IgG, hematocrit, and Brix percentage. Calves fed MC had higher 24-h IgG values (means ± SEM) than calves fed LMC-CR (27.04 ± 1.07 vs. 22.33 ± 1.08 mg/mL, respectively). Feeding 150 g of IgG from CR led to higher 24-h serum IgG values than feeding 110 g of IgG (16.90 ± 1.09 vs. 12.79 ± 1.08 mg/mL). Serum IgG levels were different between the CR-fed calves and the calves fed LMC-CR and MC, but all had average values >10 mg/mL IgG. Calves fed LMC-CR had greater AEA than calves fed MC (54.58 ± 2.39 vs. 24.38 ± 2.36%, respectively). Among calves fed CR-110 or CR-150, AEA did not differ. Serum total protein and Brix percentage had strong correlations with actual IgG values across the entire study. We found no differences in average daily gain or health variables measured, and no differences in final hip width, withers height, or body weight for calves fed MC, LMC-CR, CR-150, or CR-110. These results indicate that CR can be fed successfully as an alternative to MC or as a supplement to colostrum with low IgG.
在新生牛犊中，可以通过喂食足够数量和质量的母体初乳（MC）或初乳替代品（CR）来实现抗体的成功被动转移。另一种方法是用来自 CR 的 IgG 补充低质量的母体初乳（LMC）。本研究的目的是确定是否可以使用含有低水平酪蛋白的商业乳清基 CR 产品（Premolac PLUS 牛 IgG；Zinpro Corporation，Eden Prairie，MN）来替代 MC 或补充 LMC，从而在新生奶牛犊中达到足够的血清 IgG 水平和表观吸收率（AEA）。荷斯坦奶牛犊（每组 20 头）在出生后与母畜分离，并随机分配在出生后 1.5 小时内分别喂食 3.79 L MC（106 g/L IgG；401 g IgG 喂食）、LMC（30 g/L IgG）补充 CR（41 g/L IgG；154 g IgG 总喂食；LMC-CR）或 1.3 L 的 2 种 CR 水平之一（110 或 150 g IgG 喂食；CR-110 或 CR-150）。初乳是从宾夕法尼亚州立大学奶牛的第一次（MC）或第二次和第三次挤奶（LMC）中获得的，并按来源分成大批次。在初乳喂养前和出生后 24 小时从犊牛身上采集血液样本，并分析血清总蛋白、总 IgG、红细胞压积和 Brix 百分比。与 LMC-CR 组相比，喂食 MC 的犊牛在 24 小时 IgG 值更高（平均值 ± SEM）（分别为 27.04 ± 1.07 和 22.33 ± 1.08 mg/mL）。与喂食 110 g IgG 相比，喂食 150 g IgG 的 CR 可导致更高的 24 小时血清 IgG 值（16.90 ± 1.09 与 12.79 ± 1.08 mg/mL）。与 LMC-CR 和 MC 组相比，喂食 CR 的犊牛血清 IgG 水平不同，但所有犊牛的平均 IgG 值均>10 mg/mL。与喂食 MC 的犊牛相比，喂食 LMC-CR 的犊牛具有更高的 AEA（分别为 54.58 ± 2.39 和 24.38 ± 2.36%）。在喂食 CR-110 或 CR-150 的犊牛中，AEA 没有差异。在整个研究过程中，血清总蛋白和 Brix 百分比与实际 IgG 值有很强的相关性。我们发现，喂食 MC、LMC-CR、CR-150 或 CR-110 的犊牛的平均日增重或测量的健康变量没有差异，髋宽、肩高或体重的最终值也没有差异。这些结果表明，CR 可以成功地作为 MC 的替代品或低 IgG 初乳的补充品。
