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采用模块化双动组件和钴铬合金内金属头行翻修全髋关节置换术的患者存在血清金属离子水平升高的风险。

Patients Following Revision Total Hip Arthroplasty With Modular Dual Mobility Components and Cobalt-Chromium Inner Metal Head are at Risk of Increased Serum Metal Ion Levels.

机构信息

Orthopedic Unit, Department of Health Sciences, University of Florence, Firenze, Italy.

出版信息

J Arthroplasty. 2020 Jun;35(6S):S294-S298. doi: 10.1016/j.arth.2020.02.050. Epub 2020 Feb 28.

Abstract

BACKGROUND

Modular dual-mobility (MDM) total hip arthroplasty (THA) is designed with a cobalt-chromium liner inserted into a titanium acetabular component. The purpose of this study is to investigate the potential risks for fretting corrosion at this junction, by measuring serum metal ions, after MDM acetabular revision.

METHODS

Thirty-seven patients with well-functioning revision THAs participated in a cross-sectional study at mean 5.1 (2-10) years after surgery. All received a trabecular titanium MDM acetabular component. The serum levels of cobalt and chromium were measured using mass spectrometry.

RESULTS

The mean values of chromium and cobalt were 2.08 μg/L (95% confidence interval 0.9-3.2, range 0.02-11.8) and 1.99 μg/L (95% confidence interval 0.81-3.17, range 0.07-16.05), respectively. Eleven patients (29, 7%) had ion levels above the normal range, with 6 (16.2%) above 5 μg/L and 5 (13.5%) between 1 and 5 μg/L. A significant correlation was found between an elevated serum metal ion level and University of California Los Angeles score (P = .016).

CONCLUSION

We conclude that serum metal level elevation may occur secondary to metal debris resulting from corrosion of the index MDM THA. This potential risk should be included in the decision-making process when dealing with revision arthroplasty in young and active patients.

摘要

背景

模块化双动(MDM)全髋关节置换术(THA)的设计采用钴铬衬垫插入钛髋臼部件。本研究旨在通过测量 MDM 髋臼翻修后血清金属离子来探讨该交界处发生微动腐蚀的潜在风险。

方法

37 例功能良好的翻修 THA 患者在术后平均 5.1(2-10)年参加了一项横断面研究。所有患者均接受了多孔钛 MDM 髋臼组件。使用质谱法测量血清中钴和铬的水平。

结果

铬和钴的平均值分别为 2.08μg/L(95%置信区间 0.9-3.2,范围 0.02-11.8)和 1.99μg/L(95%置信区间 0.81-3.17,范围 0.07-16.05)。11 名患者(29%)的离子水平高于正常范围,其中 6 名(16.2%)高于 5μg/L,5 名(13.5%)在 1-5μg/L 之间。血清金属离子水平升高与加利福尼亚大学洛杉矶评分(UCLA)呈显著相关(P=0.016)。

结论

我们的结论是,血清金属离子水平升高可能继发于 MDM THR 腐蚀产生的金属碎屑。在处理年轻和活跃患者的翻修关节置换时,应将这种潜在风险纳入决策过程。

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