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儿童癌症幸存者的端粒损耗。

Telomere Attrition in Childhood Cancer Survivors.

机构信息

Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina.

Department of Neurosurgery and Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina.

出版信息

Clin Cancer Res. 2020 May 15;26(10):2281-2283. doi: 10.1158/1078-0432.CCR-20-0380. Epub 2020 Mar 20.

DOI:10.1158/1078-0432.CCR-20-0380
PMID:32198150
Abstract

Childhood cancer survivors experience substantial treatment-related morbidity and biomarkers of long-term survivor health are needed. Leukocyte telomere length is shortened in childhood cancer survivors and associates with the occurrence of numerous chronic health conditions. Healthy lifestyle factors can attenuate telomere attrition in young-adult survivors, implicating critical windows for intervention..

摘要

儿童癌症幸存者经历大量与治疗相关的发病和需要长期幸存者健康的生物标志物。白细胞端粒长度在儿童癌症幸存者中缩短，与许多慢性健康状况的发生有关。健康的生活方式因素可以减轻年轻幸存者端粒的损耗，这暗示着干预的关键窗口期。

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