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个性化干预:未来20年的现实还是遥不可及的幻想?

Personalized Interventions: A Reality in the Next 20 Years or Pie in the Sky.

作者信息

Salavitabar Arash, Armstrong Aimee K

机构信息

C.S. Mott Children's Hospital, University of Michigan Congenital Heart Center, Department of Pediatrics and Communicable Diseases, Ann Arbor, MI, USA.

Nationwide Children's Hospital, The Heart Center, Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, OH, 43205, USA.

出版信息

Pediatr Cardiol. 2020 Mar;41(3):486-502. doi: 10.1007/s00246-020-02303-4. Epub 2020 Mar 20.

Abstract

There is no better representation of the need for personalization of care than the breadth and complexity of congenital heart disease. Advanced imaging modalities are now standard of care in the field, and the advancements being made to three-dimensional visualization technologies are growing as a means of pre-procedural preparation. Incorporating emerging modeling approaches, such as computational fluid dynamics, will push the limits of our ability to predict outcomes, and this information may be both obtained and utilized during a single procedure in the future. Artificial intelligence and customized devices may soon surface as realistic tools for the care of patients with congenital heart disease, as they are showing growing evidence of feasibility within other fields. This review illustrates the great strides that have been made and the persistent challenges that exist within the field of congenital interventional cardiology, a field which must continue to innovate and push the limits to achieve personalization of the interventions it provides.

摘要

没有什么比先天性心脏病的广度和复杂性更能体现个性化医疗的必要性了。先进的成像方式如今已成为该领域的标准治疗手段,三维可视化技术的进步也在不断发展,作为术前准备的一种方式。纳入新兴的建模方法,如计算流体动力学,将推动我们预测结果能力的极限,并且这些信息可能在未来的单个手术过程中即可获取和利用。人工智能和定制设备可能很快会成为治疗先天性心脏病患者的现实工具,因为它们在其他领域的可行性证据越来越多。本综述阐述了先天性介入心脏病学领域已取得的巨大进展以及仍然存在的持续挑战,该领域必须继续创新并突破极限,以实现其所提供干预措施的个性化。

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