儿童 PET/MRI 检查中腺样体和腭扁桃体的正常 FDG 摄取。

Normal FDG uptake in the adenoids and palatine tonsils in children on PET/MRI.

机构信息

Department of Radiology, Children's Wisconsin and Medical College of Wisconsin, 8915 W. Connell Ct., Milwaukee, WI, 53226, USA.

出版信息

Pediatr Radiol. 2020 Jun;50(7):958-965. doi: 10.1007/s00247-020-04650-z. Epub 2020 Mar 20.

DOI:10.1007/s00247-020-04650-z

PMID:32198664

Abstract

BACKGROUND

Information about the normal [F-18]2-fluoro-2-deoxyglucose (FDG) uptake in the adenoids and palatine tonsils in children is not available.

OBJECTIVE

The purpose of this study was to report the range of standardized uptake values (SUVs) in the normal adenoids and palatine tonsils in children, assess for the degree of asymmetry between the right and left tonsils and evaluate for the correlation of SUVs between the adenoids and tonsils.

MATERIALS AND METHODS

Pediatric patients who had had an FDG positron emission tomography (PET)/magnetic resonance imaging (MRI) brain study in our institution from January 2018 to March 2019 were identified. Patients with a history of malignancy, adenoidectomy and/or tonsillectomy, incomplete imaging coverage of Waldeyer ring and the presence of artifact on PET/MRI were excluded. Two pediatric radiologists independently measured the mean and maximum SUVs of the right tonsil, left tonsil and the adenoids. Range, mean and standard deviation were calculated for all measurements. Ratios of SUV of the left to right tonsils and the adenoids to the tonsils were calculated. The paired t-test and Pearson's correlation test were used for statistical analysis with a P-value <0.05 considered to be significant.

RESULTS

Sixty-one PET/MRI brain scans were performed in our institution during the study period. After reviewing for exclusion criteria, 41 patients were included in the study (mean age: 10.1 years, range: 2-17 years; 19 boys and 22 girls). The mean SUV was 5.30±1.57 in the right tonsil, 5.25±1.53 in the left tonsil and 4.56±1.90 in the adenoids. The maximum SUV was 8.47±2.22 in the right tonsil, 8.45±2.18 in the left tonsil and 7.59±2.94 in the adenoids. The difference between the SUVs of the right and left tonsil was not statistically significant (P=0.69 for mean SUV and P=0.90 for maximum SUV). There was a statistically significant moderately positive correlation between the FDG uptake in the adenoids and the right and left tonsil for both mean and maximum SUV (r=0.36-0.41; P=0.008-0.022).

CONCLUSION

There is a wide variation of FDG uptake in the normal tonsils and adenoids in children. Uptake in the right and left tonsils is not significantly different. There is a moderately positive correlation between the FDG uptake in the adenoids and the tonsils.

摘要

背景

目前尚无儿童腺样体和腭扁桃体正常 [F-18]2-氟-2-脱氧葡萄糖（FDG）摄取的相关信息。

目的

本研究旨在报告儿童正常腺样体和腭扁桃体标准化摄取值（SUV）的范围，评估双侧扁桃体的不对称程度，并评估腺样体和扁桃体之间 SUV 的相关性。

材料与方法

本研究纳入了 2018 年 1 月至 2019 年 3 月期间在我院行 FDG 正电子发射断层扫描（PET）/磁共振成像（MRI）脑部研究的儿科患者。排除有恶性肿瘤病史、腺样体切除术和/或扁桃体切除术史、Waldeyer 环成像不完全以及 PET/MRI 存在伪影的患者。两名儿科放射科医生分别测量右侧扁桃体、左侧扁桃体和腺样体的平均 SUV 和最大 SUV。计算所有测量值的范围、平均值和标准差。计算左右扁桃体的 SUV 比值和腺样体与扁桃体的 SUV 比值。采用配对 t 检验和 Pearson 相关检验进行统计学分析，P 值<0.05 为差异有统计学意义。

结果

在研究期间，我院共进行了 61 次 PET/MRI 脑部扫描。在排除标准后，共有 41 例患者纳入研究（平均年龄：10.1 岁，范围：2-17 岁；男 19 例，女 22 例）。右侧扁桃体的平均 SUV 为 5.30±1.57，左侧扁桃体为 5.25±1.53，腺样体为 4.56±1.90。右侧扁桃体的最大 SUV 为 8.47±2.22，左侧扁桃体为 8.45±2.18，腺样体为 7.59±2.94。右侧和左侧扁桃体的 SUV 差异无统计学意义（平均 SUV 的 P 值=0.69，最大 SUV 的 P 值=0.90）。对于平均 SUV 和最大 SUV，腺样体和双侧扁桃体的 FDG 摄取之间均存在统计学上显著的中度正相关（r=0.36-0.41；P=0.008-0.022）。