Department of Pediatrics, University of Health Sciences Şişli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.
Department of Pediatrics, University of Health Sciences Bakırköy Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
Arch Argent Pediatr. 2020 Apr;118(2):95-101. doi: 10.5546/aap.2020.eng.95.
The aim of this study was to evaluate vitamin D levels between 12-24 monthold healthy children supplemented with vitamin D (400 IU/day) during the first year.
Descriptive-sectional study conducted between June 2015, and May 2016, in Istanbul (latitude 41ºN). Children aged 12-24 months followed up by the well-child clinic who had vitamin D supplementation in the first year were included in the study. The levels of calcium, phosphorus, alkaline phosphatase, parathyroid hormone and 25-hydroxyvitamin D [25(OH)D] were measured. Vitamin D status was defined as >20 ng/mL: sufficiency, 15-20 ng/mL: insufficiency and <15 ng/mL: deficiency.
The study was completed with 197 children. 26.9 % of children (n = 53) went on receiving supplementation after one year (mean dose 491 ± 267 IU/day). The mean 25(OH)D level was 38.0 ± 13.9 ng/mL. It was found that regular vitamin D intake under one year of age (p = 0.008) and continued support after one year of age (p = 0.042) increased level of 25(OH)D in children aged 12-24 months. Vitamin D deficiency was found in 4.1 % and vitamin D insufficiency in 7.1 %. Mother's education (p = 0.009) and use of formula (p = 0.012) were protective factors in relation to development of vitamin D deficiency or insufficiency.
The level of 25(OH)D was sufficient in 88.8 % of children aged 12-24 months receiving 400 IU/day vitamin D supplementation in the first year. Vitamin D supplementation could not be required in healthy children aged 12- 24 months who received properly vitamin D supplementation in the first year.
本研究旨在评估在第一年补充维生素 D（400IU/天）的 12-24 个月龄健康儿童的维生素 D 水平。
这是一项 2015 年 6 月至 2016 年 5 月在伊斯坦布尔（纬度 41°N）进行的描述性横断面研究。在第一年接受维生素 D 补充的接受常规儿童保健门诊随访的 12-24 个月龄儿童被纳入本研究。测量了钙、磷、碱性磷酸酶、甲状旁腺激素和 25-羟维生素 D [25(OH)D]水平。维生素 D 状态定义为>20ng/mL：充足，15-20ng/mL：不足，<15ng/mL：缺乏。
本研究完成了 197 名儿童。1 年后，有 26.9%的儿童（n=53）继续接受补充治疗（平均剂量 491±267IU/天）。平均 25(OH)D 水平为 38.0±13.9ng/mL。结果发现，1 岁以下儿童定期摄入维生素 D（p=0.008）和 1 岁后继续补充（p=0.042）可以增加 12-24 个月龄儿童 25(OH)D 水平。发现 4.1%的儿童存在维生素 D 缺乏，7.1%的儿童存在维生素 D 不足。母亲的教育程度（p=0.009）和使用配方奶（p=0.012）是与维生素 D 缺乏或不足相关的保护因素。
在第一年接受 400IU/天维生素 D 补充的 12-24 个月龄儿童中，88.8%的儿童 25(OH)D 水平充足。在第一年接受适当维生素 D 补充的健康 12-24 个月龄儿童中，可能不需要补充维生素 D。
