MBChB, Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Wellesley St, Auckland 1142, New Zealand.
Pediatrics. 2014 Jan;133(1):e143-53. doi: 10.1542/peds.2013-2602. Epub 2013 Dec 16.
To determine the vitamin D dose necessary to achieve serum 25-hydroxyvitamin D (25(OH)D) concentration ≥ 20 ng/mL during infancy.
A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks' gestation to birth, and then their infants, from birth to age 6 months, were randomly assigned to 1 of 3 mother/infant groups: placebo/placebo, vitamin D3 1000/400 IU, or vitamin D3 2000/800 IU. Serum 25(OH)D and calcium concentrations were measured at enrollment, 36 weeks' gestation, in cord blood, and in infants at 2, 4, and 6 months of age.
Two-hundred-and-sixty pregnant women were randomized. At enrollment, the proportions with serum 25(OH)D ≥ 20 ng/mL for placebo, lower-dose, and higher-dose groups were 54%, 64%, and 55%, respectively. The proportion with 25(OH)D ≥ 20 ng/mL was larger in both intervention groups at 36 weeks' gestation (50%, 91%, 89%, P < .001). In comparison with placebo, the proportion of infants with 25(OH)D ≥ 20 ng/mL was larger in both intervention groups to age 4 months: cord blood (22%, 72%, 71%, P < .001), 2 months (50%, 82%, 92%, P < .001), and 4 months (66%, 87%, 87%, P = .004), but only in the higher-dose group at age 6 months (74%, 82%, 89%, P = .07; higher dose versus placebo P = .03, lower dose versus placebo P = .21).
Daily vitamin D supplementation during pregnancy and then infancy with 1000/400 IU or 2000/800 IU increases the proportion of infants with 25(OH)D ≥ 20 ng/mL, with the higher dose sustaining this increase for longer.
确定婴儿期内血清 25-羟维生素 D（25(OH)D）浓度达到≥20ng/mL 所需的维生素 D 剂量。
在新西兰进行的一项随机、双盲、安慰剂对照试验。从 27 孕周至分娩，以及随后的婴儿，从出生至 6 月龄，孕妇及其婴儿被随机分配至 3 组母亲/婴儿组：安慰剂/安慰剂、维生素 D3 1000/400IU 或维生素 D3 2000/800IU。在入组时、妊娠 36 周时、脐血中以及婴儿 2、4 和 6 月龄时测量血清 25(OH)D 和钙浓度。
260 名孕妇被随机分配。入组时，安慰剂、低剂量和高剂量组血清 25(OH)D≥20ng/mL 的比例分别为 54%、64%和 55%。在妊娠 36 周时，干预组的这一比例均大于安慰剂组（50%、91%、89%，P<0.001）。与安慰剂相比，25(OH)D≥20ng/mL 的婴儿比例在两个干预组中更大：脐血（22%、72%、71%，P<0.001）、2 月龄（50%、82%、92%，P<0.001）和 4 月龄（66%、87%、87%，P=0.004），但仅在高剂量组中 6 月龄时更大（74%、82%、89%，P=0.07；高剂量组与安慰剂相比 P=0.03，低剂量组与安慰剂相比 P=0.21）。
在妊娠和婴儿期每天补充 1000/400IU 或 2000/800IU 维生素 D 可增加血清 25(OH)D≥20ng/mL 的婴儿比例，高剂量组维持这一增加的时间更长。
