Department of Gynecology and Obstetric, University Hospital Maggiore della Carita, Via Mazzini 28, 28100, Novara, Italy.
Department of Translational Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100, Novara, Italy.
Eur J Obstet Gynecol Reprod Biol. 2020 May;248:102-105. doi: 10.1016/j.ejogrb.2020.03.002. Epub 2020 Mar 6.
Eosinophilic gastroenteritis (EGE) is an uncommon and heterogeneous disease characterized by eosinophilic infiltration of the gastrointestinal tract. There are very few reports in literature describing pregnancies in EGE patients, and no review has ever been published. We found a total of 12 cases including one that occurred in our clinic. In 5 out of 12 cases, EGE was diagnosed after delivery and pregnancies are described as uneventful. Of the 5 patients who already had a diagnosis of EGE before pregnancy, only one registered an improvement of symptoms during gestation, while the rest had no significant changes, and their pregnancies needed to be monitored as high risk. Regarding pregnancy complications, only two patients had a pre-term delivery. Both patients had not only EGE, but a remarkable obstetrical history, that could slightly complicate the interpretation of the events that occurred in their pregnancies. More studies are necessary to demonstrate if EGE is connected with pre-term onset of labor. It's not easy to define the reasons of some patient's pre term labor, and we could suppose that a combination of different mechanisms leads to this condition of breakdown of maternal-fetal tolerance. Nevertheless, we know that spontaneous preterm labor is a syndrome attributable to multiple pathologic processes and most of them are yet to be understood. However, we cannot exclude that EGE is related to late preterm delivery. We hope that this review will provide some measures of guidance to those clinicians who must satisfy the questions of young female patients diagnosed with EGE and wishing for a pregnancy.
嗜酸细胞性胃肠炎（EGE）是一种罕见且异质性的疾病，其特征是胃肠道嗜酸粒细胞浸润。文献中很少有描述 EGE 患者妊娠的报道，也从未有过相关综述。我们共发现 12 例病例，其中包括我们科室的 1 例。在这 12 例病例中，有 5 例是在分娩后诊断出 EGE 的，妊娠过程均无异常。在 5 例孕前已确诊 EGE 的患者中，只有 1 例在妊娠期间症状有所改善，其余患者均无明显变化，需要作为高危妊娠进行监测。关于妊娠并发症，只有 2 例患者早产。这 2 例患者不仅患有 EGE，而且还有显著的产科病史，这可能会略微增加对其妊娠期间发生事件的解读难度。需要进一步的研究来证实 EGE 是否与早产有关。有些患者早产的原因难以确定，我们可以假设不同机制的组合导致了这种破坏母婴耐受的情况。然而，我们不能排除 EGE 与晚期早产有关。我们希望本综述能够为那些必须解答患有 EGE 并希望妊娠的年轻女性患者问题的临床医生提供一些指导。
