Department of Gastroenterology and Hepatology, Shimane University School of Medicine, 89-1, Enya, Izumo, Shimane, 693-8501, Japan.
J Gastroenterol. 2013 Mar;48(3):333-9. doi: 10.1007/s00535-012-0640-x. Epub 2012 Jul 31.
The clinical characteristics of Japanese patients with eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE) have not been fully clarified. For understanding the pathogenesis as well as providing support for accurate diagnosis, precise information regarding clinical characteristics of these diseases is important.
A questionnaire-based survey of EoE and EGE was conducted in 1,078 teaching hospitals. Clinical data of patients with confirmed EoE or EGE diagnosed from 2004 to 2009 were collected.
Clinical data from 26 patients with EoE and 144 patients with EGE were collected. The mean ages of patients in both groups were in the 40s. Those with EoE frequently complained of dysphagia and heartburn, and had characteristic endoscopic features such as longitudinal furrows and multiple concentric rings in the esophagus, while only 34% had peripheral eosinophilia. Patients with EGE frequently complained of abdominal pain and diarrhea, and approximately 80% of them have peripheral eosinophilia. They did not have characteristic endoscopic features helpful for diagnosis. Computed tomography (CT) findings and the presence of peripheral eosinophilia were diagnostic for EGE. EGE patients with a small intestinal involvement showed the highest peripheral eosinophil counts. Glucocorticoid administration was the most widely used treatment for these diseases and its effect was favorable for at least induction of remission.
EGE is more prevalent than EoE in Japan. Patients with EGE have abdominal pain and diarrhea, high peripheral eosinophil counts, and gastrointestinal wall thickening identifiable by CT findings, while EoE is characterized by dysphagia and characteristic endoscopic features.
日本嗜酸细胞性食管炎（EoE）和嗜酸细胞性胃肠炎（EGE）患者的临床特征尚未完全阐明。为了了解发病机制并为准确诊断提供支持，了解这些疾病的临床特征非常重要。
在 1078 家教学医院中进行了基于问卷的 EoE 和 EGE 调查。收集了 2004 年至 2009 年确诊的 EoE 或 EGE 患者的临床数据。
收集了 26 例 EoE 和 144 例 EGE 患者的临床数据。两组患者的平均年龄均在 40 多岁。EoE 患者常主诉吞咽困难和烧心，并具有特征性的内镜表现，如食管的纵向皱襞和多个同心环，而仅有 34%的患者外周血嗜酸粒细胞增多。EGE 患者常主诉腹痛和腹泻，约 80%的患者外周血嗜酸粒细胞增多。他们没有有助于诊断的特征性内镜表现。计算机断层扫描（CT）发现和外周血嗜酸粒细胞增多有助于诊断 EGE。有小肠受累的 EGE 患者外周血嗜酸粒细胞计数最高。糖皮质激素是这些疾病最广泛使用的治疗方法，其疗效至少对诱导缓解是有利的。
EGE 在日本比 EoE 更为常见。EGE 患者有腹痛、腹泻、外周血嗜酸粒细胞计数高和 CT 发现的胃肠道壁增厚，而 EoE 的特征是吞咽困难和特征性的内镜表现。
