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生酮饮食会导致小鼠低血糖的反馈调节发生改变。

Consuming a ketogenic diet leads to altered hypoglycemic counter-regulation in mice.

机构信息

Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.

Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.

出版信息

J Diabetes Complications. 2020 May;34(5):107557. doi: 10.1016/j.jdiacomp.2020.107557. Epub 2020 Feb 8.

DOI:10.1016/j.jdiacomp.2020.107557
PMID:32199771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7299499/
Abstract

Ketogenic diets (KDs) are becoming increasingly popular for the treatment of diabetes, yet they are associated with increased frequency of hypoglycemia. Here we report that mice fed a KD display blunted glucagon release to hypoglycemia and neuroglucopenia, suggesting that consuming a KD may increase the risk for iatrogenic hypoglycemia.

摘要

生酮饮食（KDs）在糖尿病治疗中的应用越来越受欢迎，但它们与低血糖的发生频率增加有关。在这里，我们报告说，喂食 KD 的小鼠对低血糖和神经低血糖的胰高血糖素释放反应迟钝，这表明食用 KD 可能会增加医源性低血糖的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8251/7299499/eed47cfbdfd1/nihms-1597602-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8251/7299499/bc62610ef85a/nihms-1597602-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8251/7299499/eed47cfbdfd1/nihms-1597602-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8251/7299499/bc62610ef85a/nihms-1597602-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8251/7299499/eed47cfbdfd1/nihms-1597602-f0002.jpg

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Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report.成人糖尿病或糖尿病前期的营养治疗：共识报告。
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Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia.在代谢健康的男性中，禁食 72 小时后神经胶质乙酸盐代谢增加，并且与低血糖易感性相关。
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The glycaemic benefits of a very-low-carbohydrate ketogenic diet in adults with Type 1 diabetes mellitus may be opposed by increased hypoglycaemia risk and dyslipidaemia.对于1型糖尿病成年患者而言，极低碳水化合物生酮饮食的血糖益处可能会被低血糖风险增加和血脂异常所抵消。
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