生酮饮食会导致小鼠低血糖的反馈调节发生改变。
Consuming a ketogenic diet leads to altered hypoglycemic counter-regulation in mice.
机构信息
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
出版信息
J Diabetes Complications. 2020 May;34(5):107557. doi: 10.1016/j.jdiacomp.2020.107557. Epub 2020 Feb 8.
Abstract
Ketogenic diets (KDs) are becoming increasingly popular for the treatment of diabetes, yet they are associated with increased frequency of hypoglycemia. Here we report that mice fed a KD display blunted glucagon release to hypoglycemia and neuroglucopenia, suggesting that consuming a KD may increase the risk for iatrogenic hypoglycemia.
摘要
生酮饮食（KDs）在糖尿病治疗中的应用越来越受欢迎，但它们与低血糖的发生频率增加有关。在这里，我们报告说，喂食 KD 的小鼠对低血糖和神经低血糖的胰高血糖素释放反应迟钝，这表明食用 KD 可能会增加医源性低血糖的风险。
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本文引用的文献
1
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JCI Insight. 2019 Jun 20;4(12). doi: 10.1172/jci.insight.128308.
2
Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report.成人糖尿病或糖尿病前期的营养治疗：共识报告。
Diabetes Care. 2019 May;42(5):731-754. doi: 10.2337/dci19-0014. Epub 2019 Apr 18.
3
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Acta Diabetol. 2018 Oct;55(10):1029-1036. doi: 10.1007/s00592-018-1180-5. Epub 2018 Jun 22.
4
Eating patterns and food intake of persons with type 1 diabetes within the T1D exchange.1 型糖尿病交换计划中 1 型糖尿病患者的饮食模式和食物摄入量。
Diabetes Res Clin Pract. 2018 Jul;141:217-228. doi: 10.1016/j.diabres.2018.05.011. Epub 2018 May 26.
5
6
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Pediatrics. 2018 Jun;141(6). doi: 10.1542/peds.2017-3349. Epub 2018 May 7.
7
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PLoS One. 2018 Mar 29;13(3):e0194987. doi: 10.1371/journal.pone.0194987. eCollection 2018.
8
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9
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Diabetes Care. 2017 Jan;40(1):132-135. doi: 10.2337/dc16-1472. Epub 2016 Oct 21.
10
From 'pleasure to chemistry': the experience of carbohydrate counting with and without carbohydrate restriction for people with Type 1 diabetes.从“愉悦到化学”：1型糖尿病患者进行碳水化合物计数并伴有或不伴有碳水化合物限制的体验
J Prim Health Care. 2015 Dec 1;7(4):291-8. doi: 10.1071/hc15291.
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