Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104, United States.
Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104, United States.
Contraception. 2020 Jun;101(6):427-431. doi: 10.1016/j.contraception.2020.03.002. Epub 2020 Mar 19.
To identify factors associated with contraceptive uptake among participants in a miscarriage management clinical trial.
We performed a secondary analysis of a multi-center, randomized controlled trial of medical management regimens for miscarriage between 5 and 12 completed weeks. Pregnancy intention was measured by patient report after miscarriage diagnosis. Participants were offered contraception in accordance with standard clinical care once their miscarriage was completed. We analyzed participants as a cohort and fit a multivariable model to describe demographic characteristics and pregnancy intentions independently associated with contraceptive uptake.
Of 244 participants with available contraceptive outcomes, 121 (50%) stated that this pregnancy was planned, and 218 (90%) stated that they had planned to continue the pregnancy to term. Ninety-seven participants (40%) initiated contraception: 33 (14%) selected a long-acting reversible method, 44 (18%) a short-acting reversible method, and 20 (8%) condoms or emergency contraception, while 147 (60%) declined contraception after miscarriage completion. In the multivariable model, unplanned pregnancy (aRR 2.13, 95% CI: 1.45-3.13) and lack of intention to continue the pregnancy (aRR 1.61, 95% CI: 1.18-2.20) were independently associated with contraceptive uptake. Of participants who declined contraception, 85 (57%) did so in order to conceive again. Nearly one-quarter of participants who declined contraception described the index pregnancy as unplanned, but after miscarriage planned to conceive a new pregnancy.
Patients with unplanned pregnancy who miscarried were twice as likely to initiate contraception as those with planned pregnancy, however pregnancy intentions sometimes changed after miscarriage.
Miscarriage management represents an important opportunity to clarify pregnancy goals and provide contraceptive counseling. Although unplanned pregnancy correlates with contraceptive uptake, we do not recommend using this clinically to predict contraceptive need. Future research should examine how best to measure pregnancy intention and its relationship to the experience of miscarriage.
确定与流产管理临床试验参与者采用避孕措施相关的因素。
我们对一项多中心、随机对照试验进行了二次分析,该试验评估了 5 至 12 周完全流产的药物治疗方案。流产后通过患者报告来测量妊娠意向。一旦流产完成,参与者将按照标准临床护理获得避孕措施。我们将参与者作为队列进行分析,并拟合多变量模型来描述与避孕措施采用独立相关的人口统计学特征和妊娠意向。
在有避孕结局的 244 名参与者中,121 名(50%)表示此次妊娠是计划内的,218 名(90%)表示他们计划继续妊娠至足月。97 名参与者(40%)开始采用避孕措施:33 名(14%)选择长效可逆方法,44 名(18%)选择短效可逆方法,20 名(8%)选择避孕套或紧急避孕药,而 147 名(60%)在流产完成后拒绝避孕。在多变量模型中,意外妊娠(ARR 2.13,95%CI:1.45-3.13)和缺乏继续妊娠意向(ARR 1.61,95%CI:1.18-2.20)与避孕措施采用独立相关。在拒绝避孕的参与者中,85 名(57%)表示为了再次怀孕。近四分之一拒绝避孕的参与者表示,指数妊娠是意外的,但流产后计划再怀一次孕。
意外妊娠且流产的患者启动避孕措施的可能性是计划妊娠且流产患者的两倍,但流产后妊娠意向有时会发生变化。
流产管理代表了澄清妊娠目标和提供避孕咨询的重要机会。尽管意外妊娠与避孕措施采用相关,但我们不建议将其用于临床预测避孕需求。未来的研究应探讨如何最好地测量妊娠意向及其与流产经历的关系。