Creighton University School of Medicine, Phoenix Regional Campus, Phoenix, AZ, USA.
Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Critical Care, and Pain Medicine, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
Curr Pain Headache Rep. 2020 Mar 21;24(5):17. doi: 10.1007/s11916-020-00854-y.
Sickle cell disease (SCD) is a hematological disorder which leads to serious complications in multiple organ systems. While significant research has addressed many of the effects of acute pain episodes and end-organ damage connected to this disease, little has approached the chronic pain state associated with this condition.
Associated chronic pain represents a significant detractor from the quality of life experienced by these patients, affecting over half of those with SCD on more days than not. Current treatment typically is centered upon preventing and responding to acute vasoocclusive crises, presumably because this is the most common reason for hospitalization in these patients. The lack of management of chronic pain symptoms leaves many with SCD in a state of suffering. In this review, the treatment methodologies of SCD patients are examined including alternative treatments, both pharmaceutical and non-pharmaceutical, as well as procedural approaches specifically aimed at reducing chronic pain in these patients.
镰状细胞病（SCD）是一种血液系统疾病，可导致多个器官系统的严重并发症。虽然大量研究已经解决了与该疾病相关的急性疼痛发作和终末器官损伤的许多影响，但很少有研究涉及与该疾病相关的慢性疼痛状态。
相关的慢性疼痛极大地降低了这些患者的生活质量，超过一半的 SCD 患者每天都会经历这种疼痛，而且这种情况比急性血管阻塞性危象更为常见。目前的治疗方法通常集中在预防和应对急性血管阻塞性危象上，这可能是因为这是这些患者住院的最常见原因。对慢性疼痛症状的管理不善，使许多 SCD 患者处于痛苦之中。在这篇综述中，我们检查了 SCD 患者的治疗方法，包括替代治疗方法，包括药物和非药物治疗方法，以及专门针对减轻这些患者慢性疼痛的程序方法。
