修复、移除和关闭：这一切都取决于 RNA 聚合酶 II 的泛素化。
Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation.
机构信息
Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea; School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
出版信息
Cell. 2020 Mar 19;180(6):1039-1041. doi: 10.1016/j.cell.2020.02.053.
PMID:32200798
Abstract
Two papers, by Nakazawa and Vidaković, show how ubiquitylation of a single lysine residue in RNA polymerase II serves as a master switch to regulate transcription, RNA polymerase II degradation, and transcription-coupled nucleotide excision repair in response to DNA damage.
摘要
两篇论文，由中沢和维达科维奇撰写，展示了 RNA 聚合酶 II 中单个赖氨酸残基的泛素化如何作为主开关，调节转录、RNA 聚合酶 II 降解以及转录偶联的核苷酸切除修复，以响应 DNA 损伤。
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