Division of Molecular Diagnostics, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan; Division of Advanced Cancer Diagnostics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Cell Chem Biol. 2020 Mar 19;27(3):253-254. doi: 10.1016/j.chembiol.2020.03.002.
Carbamoyl phosphate synthetase 1 (CPS1) drives ammonia conversion to carbamoyl phosphate, and its overexpression supports pyrimidine synthesis and tumor growth, highlighting the potential of CPS1 inhibition as a therapeutic target. In this issue of Cell Chemical Biology, Yao et al. (2020) introduce H3B-120 as a promising novel inhibitor of CPS1.
氨甲酰磷酸合成酶 1（CPS1）将氨转化为氨甲酰磷酸，其过表达支持嘧啶合成和肿瘤生长，这突显了 CPS1 抑制作为治疗靶点的潜力。在本期《细胞化学生物学》中，姚等人（2020 年）介绍了 H3B-120 作为一种有前途的新型 CPS1 抑制剂。
