Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey; ERNAM-Erciyes University Nanotechnology Application and Research Center, Kayseri, Turkey; Technology Research & Application Center (TAUM), Erciyes University, Kayseri, Turkey; Chemicamed Chemical Inc. Erciyes University Technology Development Zone, Kayseri, Turkey.
Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey; ERNAM-Erciyes University Nanotechnology Application and Research Center, Kayseri, Turkey.
Talanta. 2020 Jun 1;213:120813. doi: 10.1016/j.talanta.2020.120813. Epub 2020 Feb 8.
Accurate sensitive analysis of drug ingredient substances in biological, pharmaceutical and environmental samples and removal of drug ingredient substances in environmental samples owngreat importance for sustaining viability. The realization of these processes using a single material offers significant advantages in terms of cost, time and ease of use. In this study, TiO nanoparticles and C-Nanofibers modified magnetic FeO nanospheres (TiO@FeO@C-NFs) synthesized as a multifunctional material employing a simple hydrothermal synthesis method. This innovative material was exploited in the magnetic solid-phase extraction (MSPE) method for the preconcentration of ibuprofen and photocatalytic degradation of antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), and azo dye. To our knowledge, no studies have been previously conducted using the same material as magnetic solid-phase extraction adsorbent and magnetically separable photocatalyst. The characterization of TiO@FeO@C-NFs was carried out by XRD, FE-SEM, EDX and Raman techniques. The main analytical parameters affecting MSPE performance of ibuprofen such as pH, sorbent amount eluent type and volume and sample volume were optimized. The optimum values of the method were determined at the following parameters: pH 4.0, adsorbent amount 150 mg and eluent 2 mL of acetone. Ibuprofen analysis after MSPE was carried out using a high-performance liquid chromatography diode array detection system (HPLC-DAD). The photocatalytic degradation efficiencies of TiO@FeO@C-NF hybrid material for probe-analytes reached 80-100% and the complete degradation attained within the range of 8-125 min under UV irradiation. Simple preparation, practical isolation from solutions, high efficiency, reproducibility, and sustainability are the main advantages of the TiO@FeO@C-NFs for MSPE and photocatalytic degradation applications.
准确、灵敏地分析生物、制药和环境样品中的药物成分物质，并去除环境样品中的药物成分物质，对于维持生物的生存能力至关重要。使用单一材料实现这些过程在成本、时间和使用便利性方面具有显著优势。在本研究中，采用简单的水热合成方法合成了一种多功能材料，即 TiO 纳米粒子和 C-纳米纤维修饰的磁性 FeO 纳米球（TiO@FeO@C-NFs）。该创新材料被用于磁性固相萃取（MSPE）方法中，用于预浓缩布洛芬和光催化降解抗生素、非甾体抗炎药（NSAIDs）和偶氮染料。据我们所知，以前没有使用相同的材料作为磁性固相萃取吸附剂和可分离的磁性光催化剂的研究。TiO@FeO@C-NFs 的表征采用 XRD、FE-SEM、EDX 和拉曼技术进行。对影响布洛芬 MSPE 性能的主要分析参数，如 pH 值、吸附剂用量、洗脱剂类型和体积以及样品体积进行了优化。该方法的最佳值在以下参数下确定：pH 值 4.0、吸附剂用量 150mg 和洗脱剂 2mL 丙酮。MSPE 后使用高效液相色谱二极管阵列检测系统（HPLC-DAD）对布洛芬进行分析。在紫外光照射下，TiO@FeO@C-NF 杂化材料对探针分析物的光催化降解效率达到 80-100%，在 8-125min 范围内达到完全降解。TiO@FeO@C-NFs 用于 MSPE 和光催化降解应用的主要优点是制备简单、从溶液中实际分离、高效、重现性和可持续性。
