Sonne J, Poulsen H E, Loft S, Døssing M, Vollmer-Larsen A, Simonsen K, Thyssen H, Lundstrøm K
Department of Medicine F, Gentofte University Hospital, Copenhagen, Denmark.
Eur J Clin Pharmacol. 1988;35(1):109-11. doi: 10.1007/BF00555519.
In nine healthy volunteers, the clearance and metabolism of acetaminophen 1000 mg i.v. was evaluated with and without two concomitant oral doses of codeine in order to investigate a possible interaction. Plasma acetaminophen was followed for 720 min and urine was collected for 24 h after each dose for determination of metabolites. When codeine was coadministered, the average total clearance of acetaminophen and its clearance by glucuronidation, sulphation and mercapturate formation were 0.58 to 1.12-times the control values. It is concluded that therapeutic doses of codeine do not influence the clearance or metabolism of acetaminophen.
在9名健康志愿者中，静脉注射1000毫克对乙酰氨基酚，在有和没有同时口服两剂可待因的情况下评估其清除率和代谢情况，以研究可能的相互作用。每次给药后，监测血浆对乙酰氨基酚720分钟，并收集尿液24小时以测定代谢产物。当同时给予可待因时，对乙酰氨基酚的平均总清除率及其通过葡萄糖醛酸化、硫酸化和巯基尿酸盐形成的清除率为对照值的0.58至1.12倍。得出的结论是，治疗剂量的可待因不会影响对乙酰氨基酚的清除率或代谢。
